02739-A: The Role of the Putative Tumor Suppressor Gene SETD2 in Canine Diffuse Large B-cell Lymphoma
Lymphoma is a common, deadly cancer affecting both humans and dogs. Effective therapies without side effects are lacking. This study will investigate the role of a gene called SETD2 in the development of canine lymphoma. SETD2 is often disrupted in human cancers, including lymphoma, and preliminary data suggest a similar gene disruption in canine lymphoma. […]
03194: A Blueprint to Develop Next-Generation CAR T Therapy for Canine Lymphoma
High-grade B cell lymphoma is a cancer frequently diagnosed in older dogs, with Golden Retrievers and Bernese Mountain Dogs being particularly predisposed. Standard veterinary care involves chemotherapy and while patients initially respond well, the disease proves to be fatal for most dogs diagnosed. In human medicine, chimeric antigen receptor (CAR) T cell therapy, in which […]
02890: Characterizing the LINE-1 Transcriptome in Canine High-grade Peripheral T-cell Lymphoma by RNAseq to Gain Insight into Mechanisms of Drug and Immune Resistance
High-grade lymphomas are common cancers of white blood cells in dogs. T-cell lymphoma is a particularly aggressive form associated with poor outcomes. Chemotherapy ultimately fails in T-cell lymphoma patients because of a tiny subpopulation of cancer cells – so-called minimal residual disease (MRD) – that resists most drugs, and eventually takes over, leading to short […]
03294: Formulation of Radiopharmaceutical Cocktails with MIRDcell AI to Treat B Cell Lymphoma in Dogs
Lymphomas account for approximately 15-25% of all canine cancers and are the most common cancer of the blood and immune system in dogs, accounting for about 80% of this tumor type. Standard of care treatment for canine lymphoma is multiagent chemotherapy that results in median survival times of approximately one year. Despite advancements in the […]
02318: Genetic and Environmental Risk for Lymphoma in Boxer Dogs
Lymphoma is a fatal cancer of the blood cells that can occur in any dog. Lymphoma is more common in Boxers, Golden Retrievers, and several other purebreds, which suggests involvement of inherited genes. Recent research has focused on gene mutations in the tumors of dogs with lymphoma. However, we do not understand why these mutations […]
00415: Anti-HLA-DR Antibody Therapy in Canine B-cell Lymphoma: Preliminary Clinical Evaluation
Canine lymphoma is a frequently occurring, temporarily controllable form of cancer that is similar to high-grade non-Hodgkins lymphoma in people. The best conventional chemotherapy results in rapid improvement, but ultimately relapse and progression occur. Adjustment of current chemotherapy protocols is unlikely to result in substantial gains in survival due to development of multiple mechanisms of […]
01651: Serum Antibody Reactivity Profiling for Canine Lymphoma Detection and Monitoring
Diagnosis of canine lymphoma is complicated by the lack of a non-invasive test. Few validated biomarkers for canine lymphoma exist. We are addressing this need through our Immunosignaturing platform by demonstrating that canine lymphoma patients can be distinguished from healthy individuals. Two diagnostics of great utility to improve the quality of life of these patients […]
03102-A: Can Deep Learning (CNN) Detect Minimal Residual Disease (MRD) in Dogs Treated for Lymphoma?
Lymphoma is a common and deadly form of cancer that occurs in the lymph nodes of dogs. Determining response to chemotherapy is an important goal of cancer treatment and critical to a patient’s long-term survivability. An essential part of this monitoring process includes sampling the affected lymph nodes with a needle and examination of the […]
01418: Harnessing a Dog’s Own Immune System to Kill Lymphoma Tumor Cells
Lymphoma is the most common malignancy of dogs representing up to 25% of diagnosed cancers. Dogs often develop an aggressive form of lymphoma that is rarely curable, with most unfortunately succumbing to disease within 12 months of diagnosis despite best-available chemotherapies. Dr. Wilson will develop a new treatment to re-train the dog’s own immune system […]
01545-A: Pilot Study to Assess Folate Receptor Expression in Canine High-Grade Multicentric Lymphoma
Multicentric lymphoma is a common cancer in pet dogs. Although multicentric lymphoma can typically be controlled for several months or longer with chemotherapy, it is ultimately lethal in most dogs. This research project was important in demonstrating that half (5 of 10) of dogs with multicentric lymphoma in a pilot study had marked uptake of […]