01077-A: Characterization of a P-Type ATPase, an Integral Membrane Protein in Dog Adipose Tissue: a Novel Target for Metabolic Diseases in Mammals
Grant Status: Closed Grant Amount: $12,851.06 Madhu S. Dhar, PhD; University of Tennessee May 1, 2008 – April 30, 2009 Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., Estate of Virginia Lyn Tarquinio, German Shepherd Dog Club of America, White Shepherd Genetics Project Breed(s): -All Dogs Research Program Area: Endocrinology Donate to Support this Research […]
00631: The Genome Wide Search for the Genetic Cause of Primary Hyperparathyroidism in the Keeshond
Grant Status: Closed Grant Amount: $91,917 Richard E. Goldstein, DVM; Cornell University April 1, 2006 – September 30, 2008 Sponsor(s): Breed(s): Keeshond Research Program Area: Endocrinology Donate to Support this Research Program Area Project Summary The study of the genetic cause of cause of primary hyperparathyroidism in Keeshonden has gone very well with the majority […]
02366-A: Individualization of Pharmacological Interventions in Diabetic Dogs
Diabetes mellitus is a disease of middle-aged to older dogs which means many affected dogs will develop other diseases such as arthritis, infections, and behavior disorders, all requiring drug therapy. Poor control of glucose levels in diabetic dogs can alter how drugs behave in the body, which can result in drug toxicities. This is an […]
01235-A: Genome Wide Association Mapping to Identify Genes Associated with Hypoadrenocorticism in the Bearded Collie
Hypoadrenocorticism (canine Addison’s disease) is a late onset disorder caused by deterioration of the adrenal gland cortex and insufficient production of glucocorticoids and mineralocorticoids normally produced by that tissue; it is believed to represent an autoimmune condition. Evidence from the human literature pertaining to autoimmune diseases suggest a set of susceptibility genes that express differentially […]
01233-A: Examining Hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers Utilizing Whole Genome SNP Association
Addison’s disease in the NSDTR has a complicated presentation. Dogs have been diagnosed as early as 7 weeks of age and as old as 11 years. In some cases, other diseases are seen in conjunction with Addison’s disease like megaesophagus, hypothyroidism and eye problems. The sequencing of the canine genome has made available some powerful […]
0002044: Ultrasonic and Cytologic Evaluation of the Thyroid Gland in Golden Retriever Dogs
Ultrasound evaluation of the thyroid gland was performed in healthy, hypothyroid, and euthyroid Golden Retriever dogs with nonthyroidal illness (NTI) to determine the diagnostic usefulness of ultrasound for differentiating between euthyroid and hypothyroid dogs. Thirty-six healthy, 11 hypothyroid, and 35 euthyroid dogs with NTI were evaluated. Each thyroid lobe was examined ultrasonographically for size, shape, […]
02428: Identifying the Disease-Defining Autoantibodies in Canine Addison’s Disease
Addison’s disease is a common and life-threatening disorder in dogs in which the body’s immune system destroys the outer layer of the adrenal glands. The adrenal glands produce hormones that are critical for energy metabolism, immune system function, intestinal health, and kidney function. Symptoms of Addison’s disease can mimic other conditions, and as a result, […]
00225: Establishing a Genetic Linkage Between Addison’s Disease and DNA Markers
Addison’s disease is a late onset disorder caused by deterioration of the adrenal gland cortex. Although Addison’s disease occurs in the general canine population, the existence of Addisonian dogs repeatedly appearing in pedigrees of certain dogs led breeders to speculate that Addison’s disease is inherited. Although Addison’s disease occurs in the dog population as a […]
0002434: Recombinant Thyrotropin (TSH): Standard for the Next Generation of Canine TSH Immunoassays with Improved Sensitivity
Overall, this research project completed the genetic phase of the project and are reproducibly producing reasonable quantities of recombinant canine TSH in vitro and purifying it with high recovery to high purity. In the future, this standard can serve as a reproducible standard for all available canine TSH assays. Although the researchers did not succeed […]
01602: Defining the Cause of Hyperadrenocorticism
Hyperadrenocorticism (HAC) is a chronic debilitating disorder in dogs and contributes to the development of negative health and behavior outcomes including diabetes mellitus, obesity, musculoskeletal weakness, immune system dysfunction, and inappropriate urination. Increased serum alkaline phosphatase (ALP) activity and increased noncortisol steroids are associated with HAC. Using Scottish Terriers (due to their predisposition to atypical […]