Changes in thyroid hormone concentrations over time in dogs with autoimmune thyroiditis
Hormonal Health Research
The AKC Canine Health Foundation (CHF) supports research into diseases of the endocrine system, focusing on genetic causes, stem cell therapies, novel diagnostics, and potential treatments for hormonal disorders.
0002226: Characterizing the Inheritance of Addison’s Disease and Linked DNA Markers
Addison’s disease is a late onset disorder caused by the deterioration of the adrenal gland. Addison’s occurs in the domestic dog at approximately 0.1 percent, with some breeds showing a greater prevalence. Notably, the Bearded Collie, the West Highland White Terrier, the Standard Poodle, the Portuguese Water Dog, and the Leonberger are considered to have […]
01077-A: Characterization of a P-Type ATPase, an Integral Membrane Protein in Dog Adipose Tissue: a Novel Target for Metabolic Diseases in Mammals
Grant Status: Closed Grant Amount: $12,851.06 Madhu S. Dhar, PhD; University of Tennessee May 1, 2008 – April 30, 2009 Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., Estate of Virginia Lyn Tarquinio, German Shepherd Dog Club of America, White Shepherd Genetics Project Breed(s): -All Dogs Research Program Area: Endocrinology Donate to Support this Research […]
00631: The Genome Wide Search for the Genetic Cause of Primary Hyperparathyroidism in the Keeshond
Grant Status: Closed Grant Amount: $91,917 Richard E. Goldstein, DVM; Cornell University April 1, 2006 – September 30, 2008 Sponsor(s): Breed(s): Keeshond Research Program Area: Endocrinology Donate to Support this Research Program Area Project Summary The study of the genetic cause of cause of primary hyperparathyroidism in Keeshonden has gone very well with the majority […]
0002447: Genetic Determinants of Susceptibility to Hypothyroid Disease in Dogs
Grant Status: Closed Grant Amount: $60,473 George Happ, PhD; University of Alaska, Fairbanks October 1, 2003 – September 30, 2004 Sponsor(s): Golden Retriever Foundation, Medallion Rottweiler Club, Rottweiler Health Foundation Breed(s): -All Dogs Research Program Area: Endocrinology Donate to Support this Research Program Area Project Summary Canine hypothyroid disease is very similar to Hashimoto’s disease […]
01236-A: Hypothyroidism and Autoimmune Susceptibility Genes in the Bearded Collie
Grant Status: Closed Grant Amount: $12,128 Anita M. Oberbauer, PhD; University of California, Davis March 1, 2009 – February 28, 2010 Sponsor(s): BEACON for Health, Bearded Collie Club of America Breed(s): Bearded Collie Research Program Area: Endocrinology Donate to Support this Research Program Area Project Summary Autoimmune disorders, for which hypothyroidism is one, have been […]
00589A: Identifying Genes Regulating Addison’s Disease in the Portuguese Water Dog (PWD)
Addison’s disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance, caused by several interacting genes. […]
00589B: Identifying Genes Regulating Addison’s Disease in the Portuguese Water Dog (PWD)
Addison’s disease, or primary adrenocortical insufficiency, is characterized by destruction of the adrenal cortex, resulting in the inability to produce cortisone when stimulated with the hormone ACTH. In Portuguese Water Dogs (PWDs), this disease occurs with a frequency of 1-2 percent, and is a heritable autoimmune disease of low penetrance, caused by several interacting genes. […]
00668-A: Inheritance of Addison’s Disease in Nova Scotia Duck Tolling Retrievers
Canine hypoadrenocorticism (Addison’s Disease) is due to a deficiency in production of corticosteroids and mineralocorticoids produced by the adrenal glands. These compounds are required for proper regulation of various pathways in the body including metabolism, blood pressure and response to stress. Affected dogs can present with a variety of non-specific clinical sighs including vomiting, diarrhea, […]