00754A: Mapping of the Gene for Transitional Cell Carcinoma in the Scottish Terrier & West Highland White Terrier
Grant Status: Closed Grant Amount: $102,400.66 Deborah Knapp, DVM; Purdue University April 1, 2007 – March 31, 2009 Sponsor(s): The Foundation of the Cairn Terrier Club of America Breed(s): West Highland White Terrier, Scottish Terrier Research Program Area: Oncology Donate to Support this Research Program Area Project Summary We have successfully identified two loci associated […]
00022101T: Development of Anti-Canine Il-2R? Antibodies Using CpG Oligodeoxynucleotide Vaccination
Despite progress in treating canine lymphoma, most affected dogs eventually develop resistance to chemotherapy and succumb to their disease. In human medicine, the a subunit of the interleukin-2 receptor (IL-2Ra ) has been developed as a target for immunotherapy of chemoresistant lymphoma patients. Intensively studied as a molecule present on normal lymphocytes that are activated, […]
0001456: Immunohistochemical and Mutational Analysis of p53 in Archival Benign and Malignant Tumors of Flat-Coated Retrievers
Grant Status: Closed Grant Amount: $18,426.25 Guillermo C. Couto, DVM; Ohio State University May 7, 1997 – May 6, 1998 Sponsor(s): Flat-Coated Retriever Foundation Breed(s): Flat-Coated Retriever Research Program Area: Oncology Donate to Support this Research Program Area Project Summary Malignant histiocytosis, a form of cancer, is very common in Flat-Coated Retrievers (FCRs), but rare […]
0001626T: Significance of Tumor Suppressor Genes in Canine Cancer
Grant Status: Closed Grant Amount: $93,570 Jaime F Modiano, VMD, PhD; University of Colorado November 12, 1999 – August 31, 2000 Sponsor(s): American Boxer Charitable Foundation, Golden Retriever Foundation, Great Dane Club of America, Medallion Rottweiler Club, Rottweiler Health Foundation, Scottish Terrier Club of America Breed(s): Rottweiler, Boxer, Golden Retriever Research Program Area: Oncology Donate […]
00790: MicroRNA Profiling and MicroRNA-Based Treatment of Canine Cancers
Grant Status: Closed Grant Amount: $94,290.22 William C Kisseberth, DVM, PhD; Ohio State University April 1, 2007 – December 31, 2012 Sponsor(s): American Shetland Sheepdog Association, Estate of Dr. Judith Musladin, Golden Retriever Foundation, Scottish Terrier Club of America, Westie Foundation of America, Inc. Breed(s): -All Dogs Research Program Area: Oncology Donate to Support this […]
01064-A: Immunocytochemical Detection and siRNA-Mediated Knockdown of Survivin in Canine Lymphoma
Grant Status: Closed Grant Amount: $12,749 Douglas H Thamm, VMD; Colorado State University February 1, 2008 – July 31, 2009 Sponsor(s): Breed(s): -All Dogs Research Program Area: Oncology Donate to Support this Research Program Area Project Summary Survivin is a protein found within many cancer cells that can function to prevent cancer cells from being […]
00978-A: Isolation of the Canine Telomerase Reverse Transcriptase (TERT) Subunit and Generation of Dominant-Negative Mutants for Telomerase Inhibition
Cancer remains one of the leading causes of death in older dogs. Although surgical techniques, chemotherapy and radiation therapy have been refined over the past 30 years, for many types of cancer, survival rates remain low. Therefore, research has focused on identifying new ways to treat cancer, particularly focused on molecules and enzymes specifically produced […]
00349: Genetic Epidemiology of Cancer in the Golden Retriever
We have collected pedigrees from Golden Retrievers with cancer and constructed a large pedigree map of the affected dogs. As reported in the 1998 GRCA National Health Survey, the most common tumors have been lymphoma and hemangiosarcoma as well as other soft tissue sarcomas. These were aggressive cancers and many occurred at a young age. […]
02244-A: Beyond Peto’s Paradox with the Geriatric Peromyscus
A Collaborative Grant between Triangle Center for Evolutionary Medicine (TriCEM) and AKC Canine Health Foundation (CHF) Cancer is a heterogeneous or widely divergent collection of diseases with a similarly wide variety of outcomes, natural histories and responses to therapy. While new medical and genomic data have shed light on the molecular mechanisms causing cancer, why […]
02879: Use of CRISPR-based Genome-wide Approach for Identification of Vulnerabilities in Canine Oral Melanoma
Oral melanoma is a frequently occurring cancer in dogs. Currently there are few effective therapies for this disease. This study aims to identify the genes necessary for cancer cells to grow using a tool called CRISPR whole genome knock-out library. This tool has the capacity to shut down nearly 18,000 out of 21,000 genes in […]