0002465T: Identification and Characterization of Genetic Mutations in Canine Mast Cell Tumors
The most common malignant tumor in dogs is the mast cell tumor (MCT, a form of skin cancer), occurring with an incidence of close to 20 percent in the canine population. MCTs range from relatively benign to extremely aggressive tumors, leading to tumor spread and eventual death. Particular breeds of dog are at risk for […]
0002254B: Heritable and Sporadic Genetic Lesions in Canine Lymphoma and Osteosarcoma
Lymphoma (cancer of lymph glands) and osteosarcoma (bone cancer) are two common cancers of dogs with remarkable breed predisposition. Lymphoma accounts for approximately 20 percent of all canine tumors, and > 80 percent of cancers originating from blood cells. Osteosarcoma is the most common bone tumor in dogs, accounting for 85 percent of skeletal cancers. […]
01683-A: Improving Resection of Tumors through Enhanced Imaging
In spite of our improved understanding of cancer molecular biology, the majority of curative cancer treatments include surgical resection of the tumor. Inadequate resection of all cancerous tissue during surgery significantly contributes to the morbidity and mortality of the disease. When “curative” surgery is attempted but incomplete surgical margins are obtained, dogs can develop both […]
00990-A: Prognostic Indicators for Anal Sac Gland Carcinoma in the English Cocker Spaniel and Preparing to Map Predisposition to this Tumor
Grant Status: Closed Grant Amount: $12,678 David Sargan, MA, PhD; University of Cambridge July 1, 2007 – December 31, 2007 Sponsor(s): Samoyed Club of America Education & Research Foundation Breed(s): English Cocker Spaniel Research Program Area: Oncology Donate to Support this Research Program Area Project Summary The goal of this project was to perform a […]
0002254A: Heritable and Sporadic Genetic Lesions in Canine Lymphoma and Osteosarcoma
Lymphoma (cancer of lymph glands) and osteosarcoma (bone cancer) are two common cancers of dogs with remarkable breed predisposition. Lymphoma accounts for approximately 20 percent of all canine tumors, and > 80 percent of cancers originating from blood cells. Osteosarcoma is the most common bone tumor in dogs, accounting for 85 percent of skeletal cancers. […]
00837-A: Prognostic Significance of Ezrin Expression in Canine High-Grade Soft Tissue Sarcoma
“Soft tissue sarcomas (STS) are a group of malignant cancers arising from the skin and structures below the skin (connective tissues, muscles, and other structures), in predominately large breed dogs. These tumors tend to infiltrate through surrounding structures and destroy the normal tissue architecture. Low and intermediate grade STS are unlikely to spread to other […]
01384-A: Improved Imaging to Monitor Therapy Response of Urinary Bladder Cancer Using 3D Volume Ultrasonography
Grant Status: Closed Grant Amount: $12,960 James F. Naughton, DVM; Purdue University February 1, 2010 – July 31, 2011 Sponsor(s): National Beagle Club, Scottish Terrier Club of America, Westie Foundation of America, Inc. Breed(s): -All Dogs Research Program Area: Oncology Donate to Support this Research Program Area Project Summary The goal of this research study […]
03103: Identification of Genetic Mutations in AnalSac Carcinoma Development in English Cocker Spaniels, Part II – Validation
English Cocker Spaniels (ECSs) are about 7.3 times more predisposed to anal sac carcinoma (ASC)development than other dog breeds. Hence, there is a genetic base for ASC development in ECSs and this study aims to identify genetic factors that are causative. Funded by AKC CHF, previous studies were performed including whole genome sequencing (WGS) and […]
02446: Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma
Several breeds of dog, including Retrievers, Bernese Mountain Dogs and Rottweilers, are known to present elevated risks of cancers including histiocytic sarcoma (HS), lymphoma, and hemangiosarcoma. HS may be misdiagnosed due to clinical presentation shared with these other cancers. Due to the aggressiveness of HS and its late diagnosis, there is no known effective treatment. […]
00935B: Positional Cloning of Two Genes for Malignant Histiocytosis (MH) in the Bernese Mountain Dog
Grant Status: Closed Grant Amount: $86,400 Catherine Andre, PhD; CNRS – University of Rennes September 1, 2008 – July 31, 2010 Sponsor(s): Golden Retriever Foundation Breed(s): Bernese Mountain Dog Research Program Area: Oncology Donate to Support this Research Program Area Project Summary While rare in the general canine population, histiocytic cancers occur at a high […]