01686-A: Identifying Drugs That Will Kill Cancer Stem Cells
Grant Status: Closed Grant Amount: $11,965.85 Kristine Elaine Burgess, DVM, MS; Tufts University February 1, 2012 – January 31, 2014 Sponsor(s): Havanese Club of America, University of Minnesota – DAF for EIC Royalties Breed(s): -All Dogs Research Program Area: Oncology Donate to Support this Research Program Area Project Summary Metformin (dimethylbiguanide) is an established oral […]
01669-A: Determining the Role of Bacterial Infection in Complications after Chemotherapy
Since cancer cells lack the normal response to ‘stop replicating’ signals, the approach to treatment of this cellular proliferation is use of chemotherapeutic agents that target rapidly dividing cells. However, the use of chemotherapy also targets the patient’s own normal rapidly dividing cells (e.g., bone marrow and gastrointestinal tract). Therefore, patients receiving chemotherapy are often […]
01843: Further Investigation of the Genes Controlling Canine Leukemia to Properly Diagnose and Control the Disease
Grant Status: Closed Grant Amount: $131,265 Matthew Breen, PhD; North Carolina State University January 1, 2013 – December 31, 2014 Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., Cairn Terrier Club of America, Inc., English Cocker Spaniel Club of America, English Setter Association of America, Inc., Golden Retriever Foundation, Mastiff Club of America, Poodle Club […]
00205-A: Relationship of Clinical Stage and Ki-67 Expression to Recurrence Following Radiotherapy of Canine Intranasal Neoplasia
This study will test the usefulness of canine intranasal tumor staging systems, plus a promising biologic marker tested on a large series of dogs treated similarly for intranasal neoplasia. The intent is to identify a system that could become the benchmark of initial evaluation for this tumor type. Biologic behavior of intranasal neoplasia (INN) in […]
01054-A: Adult NeurogenesisA Source of Dog Glioblastoma Multiforme (GBMs) Brain Tumor Development
Glioblastoma multiforme (GBM), a tumor of the brain, is one of the most common and most malignant in the dog. It is found primarily in the Boxer with a 30 percent incidence. The use of modern technologies such as MRI and CT scan in veterinary practice facilitated the detection of brain tumors in dogs. Consequently, […]
03283: Investigating the Immune and Cytoreductive Activities of Gilvetmab Alone and in Combination with Indoleamine 2,3-Dioxygenase Inhibition in Canine Urothelial Carcinoma
Bladder cancer in dogs causes longstanding pain and discomfort with eventual death from the inability to urinate. In some dogs diagnosed with bladder cancer, supportive treatment with urinary catheters to alleviate urinary obstruction and intravenous fluids to support general kidney health can improve quality of life for a short period of time. However, few treatment […]
00888-A: Generation of Canine Single Chain Fragment Variable Antibody Libraries for the Identification and Targeting of Tumor-Associated Antigens in the Dog
Cancer is the leading cause of disease related death in our current canine pet population. The mainstay of cancer therapy is the systemic administration of chemotherapeutic agents that inhibit cell division and induce cell death. These agents however are not tumor-specific and frequently cause adverse side effects which limit the dose that can be given […]
01410A: Positional Cloning of Histiocytic Sarcoma (HS) in the Bernese Mountain Dog (BMD) and Flat Coated Retriever (Part A – See also 01410B)
Grant Status: Closed Grant Amount: $50,000 Elaine A Ostrander, PhD; National Human Genome Research Institute January 1, 2011 – December 31, 2011 Sponsor(s): American Bouvier des Flandres Club – Bouvier Health Foundation, American Bullmastiff Association, American German Shepherd Dog Charitable Foundation, Inc., American Miniature Schnauzer Club, Inc., Australian Shepherd Health & Genetics Institute, Australian Terrier […]
00366: Molecular Control of COX-2 Expression and Regulation of Prostaglandin Transport in Canine Mammary Tumors
Tumors originating from the mammary gland represent one of the most frequent forms of cancer in female dogs. However, very little information is known about the mechanisms involved in the development of this cancer. In dogs, the growth of mammary tumors can recur following surgical excision or cancerous cells can appear in distant organs. Cyclooxygenase-2 […]
03368: Liquid Biopsy for Early Relapse Detection and Improved Treatment of Canine Mast Cell Tumors
Mast cell tumor (MCT) is the most common malignant canine skin tumor, accountingfor 16-21% of all skin tumors. Clinical management decisions are difficult because of thechallenging biological behavior of some MCTs and the inaccuracy of predictive and prognosticbiomarkers or other molecular descriptors (i.e., c-KIT staining pattern and mutation status, KI-67,AgNOr). While surgery is the mainstay […]