01212-A: Phenotypic Characterization of Peripheral Nerve Disease in Degenerative Myelopathy Dogs
Degenerative myelopathy (DM) is a disease of the spinal cord causing progressive weakness in the hind limbs which progresses to affect the front limbs and shows signs also in the muscles and nerves. Though most commonly reported in German Shepherds, high disease prevalence also exists in other breeds, such as Cardigan and Pembroke Welsh Corgis […]
01849: Filling the Gaps in the Canine Genome
The sequencing of the genome of man’s best friend in 2005 has provided an invaluable resource to the canine research community, and has reinforced the position of the dog as an important model organism to study human physiology and disease. Unlike the human and the rodent models (the mouse and the rat), very few dog […]
02164-MOU: Determining the Genetic Contribution to Boxer Corneal Ulcers
Spontaneous chronic corneal epithelial defects (SCCEDs) are chronic corneal ulcers that fail to undergo normal healing that are commonly observed in Boxers. The predilection for Boxers suggests that SCCEDs is inherited in this breed. Affected dogs develop spontaneous corneal ulcers that are often exceptionally painful and persist for weeks to months. Most dogs require surgical […]
02991-A: Investigating Extracellular Crosstalk Between Canine Osteosarcoma and Macrophages
Osteosarcoma is the most common bone tumor in dogs, with increased risk for large and giant breeds. Osteosarcoma is an aggressive disease, and most dogs succumb to metastatic disease in the lungs, regardless of treatment. Tumors survive and thrive by reprogramming the host immune response to ignore abnormal tumor cells and even promote their growth […]
0001428: Inheritance Patterns and Molecular Genetic Analysis of Doberman Pinschers and Boxer Dogs with Familial Dilated Cardiomyopathy
This study found that ventricular arrhythmias in Boxers are inherited as an autosomal dominant trait. Researchers found that asymptomatic Boxers have frequent ventricular premature complexes (VPCs), a specific type of irregular heartbeat that is a common form of ventricular arrhythmia. They determined that a two- to three-minute electrocardiogram (ECG) is a poorly sensitive indicator of […]
01782: Defining the Elements of Successful Cranial Cruciate Ligament Repair
In our study, we investigated four common CrCL-deficient stifle surgical stabilization techniques. We implemented the tibial plateau leveling osteotomy (TPLO), tibial tuberosity advancement (TTA), lateral femorotibial suture (LFTS) and TightRope (TR) techniques in our computer simulation model working closely with a veterinary orthopedic surgeon. Caudal cruciate ligament, lateral collateral ligament, and medial collateral ligament loads, […]
02910: Open-Label, Phase-2 Clinical Trial of Chlorambucil and Toceranib for Canine Mast Cell Tumors
Mast cell tumor (MCT) is the most common malignant canine skin tumor. Although all breeds are at risk, Boxers, Boston Terriers, Bulldogs, Labrador Retrievers, Beagles, Viszlas, Rhodesian Ridgebacks, Weimaraners, Shar-Peis and Schnauzers are predisposed. While surgery remains the main treatment for most MCT, a subset have a high potential for eventual recurrence and metastasis and […]
00591: In Vitro Effects of the Milk Thistle Extract Silibinin in Canine Tumor Cells
Many forms of canine cancer are currently incurable, and novel treatments are needed. The phytochemical silibinin, the bioactive constituent in the herb milk thistle, has been shown to induce growth arrest and apoptosis, inhibit angiogenesis, and decrease tumor cell invasion in various human tumor cells, and inhibit tumor growth in a variety of mouse models […]
02163-MOU: Is Hypothyroidism a Contributor to Progression of Arrhythmogenic Right Ventricular Cardiomyopathy?
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in the Boxer dog is an adult onset, familial disease characterized by the presence of ventricular arrhythmias, fainting and sudden death. Dr. Meurs research group identified a causative mutation in the cardiac Striatin gene that is highly associated with the development of Boxer ARVC. They have demonstrated that some Boxer […]
02772: Identifying Early Stage Ultra-rare Mutations as Predictive Biomarkers of Lymphoma in High-risk versus Low-risk Breeds Within the Dog Aging Project
The most common type of cancer in dogs is lymphoma, with ~80,000 cases diagnosed annually in the United States. Breeds vary in their risk of lymphoma, but it is unclear why there is variation despite considerable effort to identify the genetics of cancer risk and progression in dogs. Cancer typically arises from the accumulation of […]