01937-B: Evaluating the Complex Genetic Basis of Bloat
Gastric dilatation and volvulus (GDV), or bloat, is a common condition in large and giant breed dogs with an unacceptably high morbidity and mortality rate. Due to the importance of GDV in many dog breeds, several previous studies have investigated potential risk factors for the development of GDV. It is known that there is no […]
02992-A: Sentinel Lymph Node Mapping for Dogs with Lung Tumors
Canine lung cancer is a devastating disease with minimal progress over the last 20 years. One of the important aspects of staging in dogs with lung cancer is the assessment for lymph node spread. Due to the small size of the lung-associated lymph nodes, these lymph nodes are often not removed at the time of […]
02164-MOU: Determining the Genetic Contribution to Boxer Corneal Ulcers
Spontaneous chronic corneal epithelial defects (SCCEDs) are chronic corneal ulcers that fail to undergo normal healing that are commonly observed in Boxers. The predilection for Boxers suggests that SCCEDs is inherited in this breed. Affected dogs develop spontaneous corneal ulcers that are often exceptionally painful and persist for weeks to months. Most dogs require surgical […]
02991-A: Investigating Extracellular Crosstalk Between Canine Osteosarcoma and Macrophages
Osteosarcoma is the most common bone tumor in dogs, with increased risk for large and giant breeds. Osteosarcoma is an aggressive disease, and most dogs succumb to metastatic disease in the lungs, regardless of treatment. Tumors survive and thrive by reprogramming the host immune response to ignore abnormal tumor cells and even promote their growth […]
0001428: Inheritance Patterns and Molecular Genetic Analysis of Doberman Pinschers and Boxer Dogs with Familial Dilated Cardiomyopathy
This study found that ventricular arrhythmias in Boxers are inherited as an autosomal dominant trait. Researchers found that asymptomatic Boxers have frequent ventricular premature complexes (VPCs), a specific type of irregular heartbeat that is a common form of ventricular arrhythmia. They determined that a two- to three-minute electrocardiogram (ECG) is a poorly sensitive indicator of […]
01782: Defining the Elements of Successful Cranial Cruciate Ligament Repair
In our study, we investigated four common CrCL-deficient stifle surgical stabilization techniques. We implemented the tibial plateau leveling osteotomy (TPLO), tibial tuberosity advancement (TTA), lateral femorotibial suture (LFTS) and TightRope (TR) techniques in our computer simulation model working closely with a veterinary orthopedic surgeon. Caudal cruciate ligament, lateral collateral ligament, and medial collateral ligament loads, […]
02910: Open-Label, Phase-2 Clinical Trial of Chlorambucil and Toceranib for Canine Mast Cell Tumors
Mast cell tumor (MCT) is the most common malignant canine skin tumor. Although all breeds are at risk, Boxers, Boston Terriers, Bulldogs, Labrador Retrievers, Beagles, Viszlas, Rhodesian Ridgebacks, Weimaraners, Shar-Peis and Schnauzers are predisposed. While surgery remains the main treatment for most MCT, a subset have a high potential for eventual recurrence and metastasis and […]
00591: In Vitro Effects of the Milk Thistle Extract Silibinin in Canine Tumor Cells
Many forms of canine cancer are currently incurable, and novel treatments are needed. The phytochemical silibinin, the bioactive constituent in the herb milk thistle, has been shown to induce growth arrest and apoptosis, inhibit angiogenesis, and decrease tumor cell invasion in various human tumor cells, and inhibit tumor growth in a variety of mouse models […]
02772: Identifying Early Stage Ultra-rare Mutations as Predictive Biomarkers of Lymphoma in High-risk versus Low-risk Breeds Within the Dog Aging Project
The most common type of cancer in dogs is lymphoma, with ~80,000 cases diagnosed annually in the United States. Breeds vary in their risk of lymphoma, but it is unclear why there is variation despite considerable effort to identify the genetics of cancer risk and progression in dogs. Cancer typically arises from the accumulation of […]
02057: Identification of the Genetic Cause of Corneal Ulcers
Spontaneous chronic corneal epithelial defects (SCCEDs) describe an eye disorder characterized by chronic corneal ulcers that fail to undergo normal healing. The predilection of certain breeds suggests that SCCEDs is inherited. Affected dogs develop spontaneous corneal ulcers that are often exceptionally painful and persist for weeks to months. Most dogs require surgical therapy to heal […]