01609: Use of Probiotic to Reduce the Symptoms of Inflammatory Bowel Disease
Idiopathic inflammatory bowel disease (IBD) is a common cause of chronic gastrointestinal disease in dogs. Accumulating evidence in human IBD and animal models suggests that imbalances in composition of the intestinal microbiota contribute to the pathogenesis of chronic intestinal inflammation. Recent studies have also shown that dogs with IBD have distinctly different duodenal microbial communities […]
02318: Genetic and Environmental Risk for Lymphoma in Boxer Dogs
Lymphoma is a fatal cancer of the blood cells that can occur in any dog. Lymphoma is more common in Boxers, Golden Retrievers, and several other purebreds, which suggests involvement of inherited genes. Recent research has focused on gene mutations in the tumors of dogs with lymphoma. However, we do not understand why these mutations […]
02550: The Role of Bartonella spp. Exposure and Cardiac Genetic Variation on the Clinical Expression of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in the Boxer dog is an adult onset, familial disease characterized by the presence of ventricular arrhythmias, fainting and sudden death. The investigators have identified a causative mutation in the cardiac Striatin gene that is highly associated with the development of Boxer ARVC, and have demonstrated that some Boxer dogs […]
03172: Identification of Genetic Risk Factors for Gingival Enlargement in Boxers
Gingival enlargement (GE) is an overgrowth of the gums that can lead to tooth loss, impaired chewing and eating, and mouth ulcers. Treatment involves surgical removal of the excess tissue, followed by a painful recovery. In dogs, this dental disease occurs most often and with greatest severity in Boxers, indicating a breed genetic predisposition. The […]
02806-MOU: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up
The Shine On project is designed to utilize complementary technologies to reduce the impact of hemangiosarcoma in companion dogs. This novel, potentially disruptive approach is the first of its kind where artificial intelligence applied to the results of a blood test will be used to assign dogs to a risk category for the development of […]
01445: Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing
Granulomatous colitis (GC) is a severe inflammatory bowel disease (IBD), typically diagnosed in Boxer dogs younger than four years of age. Affected dogs present with hemorrhagic diarrhea, often progressing to weight loss, anemia, hypoalbuminemia, and chronic debilitation. Recent studies have identified invasive Escherichia coli within macrophages in diseased intestinal tissue, and eradication of E. coli […]
02658: Characterization of Sensory Neuronal and Muscle Pathology in Canine Degenerative Myelopathy to Identify Targets for Therapeutic Intervention
Many dog breeds, including mixed breeds, carry genetic mutations for degenerative myelopathy (DM), a late adult-onset disease that begins with loss of coordination and progressive hind limb paralysis. The disease is particularly prevalent in Boxers and Pembroke Welsh Corgis, and is similar to amyotrophic lateral sclerosis (ALS) in people. Approximately two to three years after […]
01937-B: Evaluating the Complex Genetic Basis of Bloat
Gastric dilatation and volvulus (GDV), or bloat, is a common condition in large and giant breed dogs with an unacceptably high morbidity and mortality rate. Due to the importance of GDV in many dog breeds, several previous studies have investigated potential risk factors for the development of GDV. It is known that there is no […]
02992-A: Sentinel Lymph Node Mapping for Dogs with Lung Tumors
Canine lung cancer is a devastating disease with minimal progress over the last 20 years. One of the important aspects of staging in dogs with lung cancer is the assessment for lymph node spread. Due to the small size of the lung-associated lymph nodes, these lymph nodes are often not removed at the time of […]
02437-MOU: Characterization of Renal Disease in American Boxer Dogs
Chronic kidney disease (CKD) is often a progressive and fatal disease in dogs. Boxer dogs appear to have a predisposition for development of CKD, suggesting that kidney disease in this breed might be heritable. Studies in Europe report an increased frequency of Boxers with kidney and urinary tract maldevelopments leading to CKD, termed “juvenile nephropathy”. […]