01766: Identification and Validation of the Genes That Define Abnormal Development of the Kidney in Dogs
Abnormal development of the kidneys, known as Renal Dysplasia, occurs in many breeds of dogs as well as humans. An increased prevalence in certain breeds such as Boxers, Miniature Schnauzers, Bedlington Terriers, Lhasa Apsos, Shetland Sheepdogs, and Soft Coated Wheaten Terriers suggests a genetic influence. Identification of the genetic cause in dogs is essential as […]
00821: Phenotypic Characterization and Mapping Genes Associated with Canine Degenerative Myelopathy in the Boxer Dog
Grant Status: Closed Grant Amount: $176,272 Joan R. Coates, DVM; University of Missouri, Columbia April 1, 2007 – March 31, 2010 Sponsor(s): Breed(s): Boxer Research Program Area: Neurology Donate to Support this Research Program Area Project Summary Degenerative myelopathy (DM) is a disease of the spinal cord causing progressive weakness and paralysis in the rear […]
03368: Liquid Biopsy for Early Relapse Detection and Improved Treatment of Canine Mast Cell Tumors
Mast cell tumor (MCT) is the most common malignant canine skin tumor, accountingfor 16-21% of all skin tumors. Clinical management decisions are difficult because of thechallenging biological behavior of some MCTs and the inaccuracy of predictive and prognosticbiomarkers or other molecular descriptors (i.e., c-KIT staining pattern and mutation status, KI-67,AgNOr). While surgery is the mainstay […]
00022101T: Development of Anti-Canine Il-2R? Antibodies Using CpG Oligodeoxynucleotide Vaccination
Despite progress in treating canine lymphoma, most affected dogs eventually develop resistance to chemotherapy and succumb to their disease. In human medicine, the a subunit of the interleukin-2 receptor (IL-2Ra ) has been developed as a target for immunotherapy of chemoresistant lymphoma patients. Intensively studied as a molecule present on normal lymphocytes that are activated, […]
01213-A: Determination of Outcome Measures for Clinical Progression and Morphometric Studies of Spinal Cord Disease in Degenerative Myelopathy Dogs
Degenerative myelopathy (DM) is a disease of the spinal cord causing progressive weakness in the hind limbs in adult dogs. Though most commonly reported in German Shepherds, high disease prevalence also exists in other dog breeds, such as Cardigan and Pembroke Welsh Corgis (PWC), Rhodesian Ridgebacks, and Boxer dogs. Genome-wide association mapping and a candidate […]
01759: Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma
Grant Status: Closed Grant Amount: $233,914 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2013 – December 31, 2015 Sponsor(s): American Belgian Tervuren Club, Inc., American Bouvier des Flandres Club – Bouvier Health Foundation, American German Shepherd Dog Charitable Foundation, Inc., American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics […]
01271A: Mapping of Additional Genes Associated with Canine Degenerative Myelopathy
Grant Status: Closed Grant Amount: $95,866 Kerstin Lindblad-Toh, PhD; Broad Institute January 1, 2010 – March 31, 2012 Sponsor(s): American German Shepherd Dog Charitable Foundation, Inc., American Pointer Club, Collie Health Foundation, German Shepherd Dog Club of America, Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, National Beagle Club, Staffordshire […]
0001626T: Significance of Tumor Suppressor Genes in Canine Cancer
Grant Status: Closed Grant Amount: $93,570 Jaime F Modiano, VMD, PhD; University of Colorado November 12, 1999 – August 31, 2000 Sponsor(s): American Boxer Charitable Foundation, Golden Retriever Foundation, Great Dane Club of America, Medallion Rottweiler Club, Rottweiler Health Foundation, Scottish Terrier Club of America Breed(s): Rottweiler, Boxer, Golden Retriever Research Program Area: Oncology Donate […]
01753: Identification of Genetic Factors That Alter the Severity of Cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy is a genetic-based heart disease in adult dogs that was recently found to be due to a deletion mutation in the striatin gene. Dogs with this genetic mutation can suffer from irregular heartbeat, loss of consciousness and sudden death. Dr. Meurs’ lab has demonstrated that Boxer dogs with 2 copies of […]
01429: Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma
Grant Status: Closed Grant Amount: $100,000 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2011 – June 30, 2013 Sponsor(s): American Bullmastiff Association, Boston Terrier Club of America, Briard Club of America Health & Education Trust, Flat-Coated Retriever Foundation, Golden Retriever Foundation, Plum Creek Kennel Club of Colorado, Rhodesian Ridgeback Club of the […]