03470: Genetic Investigation of Hereditary Diseases in Boxers: Juvenile Renal Dysplasia and Granulomatous Colitis
Juvenile renal disease (JRD) and granulomatous colitis (GC) are two serious diseases disproportionately affecting Boxers. JRD is a congenital kidney disorder that often leads to kidney failure early in life, while GC is a severe form of inflammatory bowel disease (IBD) linked to bacterial infection. Both diseases typically affect young dogs and can be fatal. […]
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03403: Characterization and Prognostic Evaluation of Infiltrative Immune Cells in Canine Soft Tissue Sarcomas
Soft tissue sarcomas (STS) are a commonly encountered cancer in dogs. Local recurrence of the tumor is a risk for tumors incompletely removed by surgery. Local recurrence and subsequent treatment can have a significant impact on dogs and owners. In addition, dogs with advanced STS or STS that have spread elsewhere in the body have […]
03368: Advancing Canine Health: Liquid Biopsy for Early Relapse Detection and Improved Treatment of Mast Cell Tumors
Lay Abstract: Mast cell tumor (MCT) is the most common malignant canine skin tumor, which accounts for 16~21% of all skin tumors. Although all breeds have a potential risk for developing MCTs, many pure breeds(e.g., Boxers, Boston Terriers) are predisposed, resulting in a high disease incidence. Despite the efforts, clinical management decisions are difficult because […]
02050: Granulomatous Colitis In Boxer Dogs and French Bulldogs: Mapping of Disease Associated Loci and Functional Analysis of Bacterial Killing
Granulomatous colitis is a severe inflammatory bowel disease (IBD), usually diagnosed in young dogs. Affected dogs present with hemorrhagic diarrhea, often progressing to weight loss and debilitation. Recent studies have identified invasive Escherichia coli (E. coli) bacteria within macrophages in the inflamed large intestine, and eradication of E.coli induces dramatic clinical and histologic improvement. Unfortunately, […]
0002303: Molecular Analysis of Familial Ventricular Arrhythmias in the Boxer Dog
A heart muscle disease in the Boxer dog was initially documented in the 1980s and referred to as Boxer cardiomyopathy. Studies have confirmed that this is an inherited disease primarily characterized by an electrical disturbance in the heart that may lead to collapsing episodes and sudden death. There is increasing demand for a screening test […]
0002306: Evaluation of the Geographical Variation in Familial Nature and Inheritance Patterns of Boxer Dogs with Familial Ventricular Arrhythmias
Heart disease in the Boxer dog was initially documented in the 1980s and referred to as Boxer cardiomyopathy. Recent studies have confirmed that this disease is inherited and is primarily characterized by disturbances in the cardiac electrical system, fainting episodes and sudden death. The inherited nature of the disease has led to increased interest in […]
00228: A Comparative Evaluation of the Concealed and Overt Forms of Arrhythmogenic Right Ventricular Cardiomyopathy: Risk Factors Associated with the Development of Symptoms in Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy
The clinical syndrome characterized by ventricular arrhythmias, collapsing episodes, sudden cardiac death and, sometimes, heart failure in the Boxer was previously referred to as Boxer Cardiomyopathy. More recent studied have demonstrated striking similarities, including the inheritance, to a human disease called Arrhythmogenic Right Venticular Cardiomyopathy (ARVC). The familial nature as well as the devastating outcome […]
0001626: Significance of Tumor Suppressor Genes in Canine Cancer
The research conducted in this study will provide the basis for future research that may, ultimately, lead to scientists being able to provide a better assessment of individuals’ risks for cancer (or for cancer in progeny), as well as determine whether a given dog is a good candidate for a given therapy. This project has […]
02165-MOU: Identification of Biomarkers and Therapeutic Targets for Canine Degenerative Myelopathy: The Search for A Cure
Degenerative myelopathy (DM) is an adult onset disease of the spinal cord causing progressive weakness and paralysis of the hind limbs and eventually all limbs. Mutations in an enzyme that converts superoxide to water and hydrogen peroxide, superoxide dismutase 1 (SOD1), have been linked to DM and amyotrophic lateral sclerosis (ALS-Lou Gehrig’s disease). DM is […]