0002250: Diet-Related Taurine Deficiency in Newfoundland Dogs and Associated Cardiac Insufficiency
Dilated cardiomyopathy (DCM) is the most common acquired cardiovascular disease of dogs. Of suggested nutritional causes, taurine deficiency appears most evinced. But in dogs, such a need for dietary taurine is not generally recognized. Dogs are known to have the metabolic capacity to synthesize taurine from the dietary sulfur amino acids, cysteine and methionine (Hayes […]
0002266: Linkage Analysis of Familial Dilated Cardiomyopathy in the Doberman Pinscher
Dilated cardiomyopathy (DCM), a primary heart muscle disorder characterized by poor cardiac function, is inherited in the Doberman Pinscher. Therapy for DCM does not cure or even successfully control the clinical signs. The inability to control the disease has led to increased interest in disease prevention. Prevention will likely be achieved through careful selection of […]
01859-A: Defining the Significance of Irregular Heartbeats through Early Monitoring
We have completed the data collected on 25 normal Saluki dogs in this study. All dogs included in the study were found to be normal on physical examination and had no significant abnormalities noted on an echocardiogram performed by a board certified veterinary cardiologist. Ambulatory electrocardiogram monitors (Holter monitors) were placed on the Salukis and […]
0001656: Cellular, Biochemical and Molecular Biological Analysis of Dilated Cardiomyopathy in Portuguese Water Dogs
Grant Status: Closed Grant Amount: $49,990 Joseph Alroy, DVM; Tufts University July 29, 1998 – July 28, 2000 Sponsor(s): Movers & Shakers Portuguese Water Dog Club, Portuguese Water Dog Club of America, Inc. Breed(s): Portuguese Water Dog Research Program Area: Cardiology Donate to Support this Research Program Area Project Summary Researchers in this study found […]
01694-A: Progression of “Silent” Degenerative Mitral Valve Disease in Norfolk Terriers
Grant Status: Closed Grant Amount: $8,775 Mark A. Oyama, DVM; University of Pennsylvania November 1, 2011 – October 31, 2012 Sponsor(s): Friends of Norfolk Terrier Breed(s): Norfolk Terrier Research Program Area: Cardiology Donate to Support this Research Program Area Project Summary These data indicate that dogs with previously diagnosed silent MR experienced significant changes in […]
0001419: Inheritance and Molecular Genetic Evaluation in Newfoundlands and Golden Retrievers with Subvalvular Aortic Stenosis
Analysis of blood samples and pedigrees of Newfoundlands and Golden Retrievers indicates that subvalvular aortic stenosis (SAS), a thickening of a specific part of the heart wall, is likely inherited as an autosomal dominant pattern with variable penetrance (varying degrees of symptoms and signs). SAS can be hard to study because the hearts of affected […]
01313: Identification of a Genetic Marker for Familial Aortic Stenosis in the Rottweiler
Grant Status: Closed Grant Amount: $27,651 Kathryn M Meurs, DVM, PhD; Washington State University January 1, 2010 – December 31, 2010 Sponsor(s): American Shetland Sheepdog Association, National Beagle Club, Scottish Terrier Club of America, Westie Foundation of America, Inc. Breed(s): Rottweiler Research Program Area: Cardiology Donate to Support this Research Program Area Project Summary Subvalvular […]
00789: Identification of Candidate Genes Causative for Dilated Cardiomyopathy in the Dog
Grant Status: Closed Grant Amount: $111,527 Keith E. Murphy, PhD; Texas A&M University April 1, 2007 – September 30, 2009 Sponsor(s): Great Dane Club of America, Great Dane Club of America Charitable Trust Breed(s): Great Dane Research Program Area: Cardiology Donate to Support this Research Program Area Project Summary The initial goal of this project […]
00228T: A Comparative Evaluation of the Concealed and Overt Forms of Arrhythmogenic Right Ventricular Cardiomyopathy: Risk Factors Associated with the Development of Symptoms in Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy
The clinical syndrome characterized by ventricular arrhythmias, collapsing episodes, sudden cardiac death and, sometimes, heart failure in the Boxer was previously referred to as Boxer cardiomyopathy. More recent studied have demonstrated striking similarities, including the inheritance, to a human disease called Arrhythmogenic Right Venticular Cardiomyopathy (ARVC). The familial nature as well as the devastating outcome […]
02101-MOU: Whole Genome Sequencing for Great Dane Dilated Cardiomyopathy
DNA samples were obtained from 3 affected Great Danes, 1 unaffected Labrador retriever and 1 unaffected Great Dane (Controls). We performed DNA sequencing and identified DNA variations that were only in affected dogs. We also evaluated 2 affected dogs sequenced by Dr. Leigh Anne Clark at Clemson. We found over 137,000 DNA variations that were […]