00908: Serotonin Type 2A Receptor Antagonist Therapy for Preventing the Progression of Myxomatous Mitral Valve Disease
Background: Canine myoxmatous mitral valve disease is very common in older dogs and is similar to the human disorder. Serotonin (5HT) related mechanisms has been found in the certain forms of human heart valve disease, and a beginning study by the investigators has shown heightened 5HT signaling in diseased canine mitral valve interstitial cells (MVIC). […]
00828-A: Investigation of genes identified by a canine-specific microarray may support a deficiency in cholesterol biosynthesis in the Havanese
The Havanese is a toy breed in which a large number of dogs present, from birth, with a wide range of abnormalities. Bowed, shortened, or asymmetric legs occur with the highest frequency. Eye, liver, heart, testes, and dental abnormalities are also common in the breed. The organs that are affected in the Havanese are also […]
03274: Multimodal Quantification of Mitral Regurgitation in Dogs with Myxomatous Mitral Valve Disease
Dogs can suffer from a common heart condition called Myxomatous Mitral Valve Disease (MMVD), which can lead to heart failure. Currently, this condition is managed using medication and monitoring symptoms. However, there are new treatments like open-heart mitral valve repair that can greatly improve outcomes. The challenge lies in accurately assessing the severity of the […]
02661: Investigation into Diet-Associated Dilated Cardiomyopathy in Dogs
Co-investigators: Lisa Freeman, DVM, PhD and John Rush, DVM, MS, Tufts University; Rebecca Stepien, DVM, MS, University of Wisconsin, Madison; Amara Estrada, DVM and Margaret Sleeper, VMD, University of Florida; Joshua Stern, DVM, PhD, University of California, Davis Dilated cardiomyopathy (DCM) is a serious disease of the heart muscle whereby the heart becomes enlarged with […]
02388-MOU: Genetic Markers for Familial Subvalvular Aortic Stenosis in Newfoundlands
Subvalvular Aortic Stenosis (SAS) is a heart defect characterized by a fibrous ridge located below the aortic valve. Affected dogs are at risk of developing heart valve infections, congestive heart failure or sudden death. Severely affected dogs have an average lifespan of 19 months. A previous study identified a single gene mutation associated with a […]
0002267: Linkage Analysis of Familial Subvalvular Aortic Stenosis in the Newfoundland Dog
Subvalvular Aortic Stenosis (SAS) is a familial congenital heart disease characterized by a fibrous ridge located below the aortic valve. Affected dogs are at risk of developing an infection on the aortic valve, congestive heart failure or sudden death. This is a familial defect in the Newfoundland dog; therefore affected dogs should not be bred. […]
0001660: Determination of Viral Contribution to Cardiac Disease in a Select Population of Salukis
Using cardiac tissue banked in a major effort by Saluki breeders, researchers studied tissue from 32 Salukis with cardiac problems. They screened the tissue for four viruses, including parvo and distemper, using nucleic amplification methods. They did not detect a viral contribution to cardiac disease in these dogs, though they could not rule out that […]
00900-A: Immunological Treatment of Canine Dilated Cardiomyopathy Using a T-Lymphocyte Modulator
Large breed dogs are predisposed to developing dilated cardiomyopathy (DCM), a disease that causes the heart to enlarge and not function properly, leading to heart failure and death. Current drug treatments improve the function of the heart and control the signs of congestive heart failure but do not address the underlying cause. Although the precise […]
03031: Tolerability and Clinical Efficacy of Oral Potassium Chloride Supplementation for Treatment of Hypochloremia in Canine Congestive Heart Failure
Congestive heart failure (CHF) is a very common heart condition in older, small breed dogs. Dogs with CHF almost always die of their disease or complications associated with medications used to treat CHF and therefore this is a significant health concern for dogs. Although medications can increase the quality and quantity of life, additional treatment […]
02808-MOU: Identification of a Second Genetic Risk Allele(s) Associated with the Development of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited heart disease diagnosed most commonly in the Boxer dog. Investigators previously identified the first known causative mutation for ARVC in the dog in the striatin gene. However, this mutation does not explain all affected canine cases. As in the human form of ARVC, there appears to be […]