01930-A: Development of Minimally Invasive Laparoscopic Surgery as a Definitive Diagnostic Tool for Gastrointestinal Obstruction
The results of this study have shown that using a laparoscope for gastrointestinal exploratory for simple GI foreign bodies is feasible and safe. Organs were accessible for the laparoscopic portion with few exceptions (ileocecolcolic junction, duodenum). The final diagnosis was consistent in all cases between the laparoscopic and open techniques (100% agreement). There were no […]
01074-A: The Role of Enteropathogenic Bacteria in Diarrhea in Racing Alaskan Sled Dogs
This is the first study to attempt to establish an apparent prevalence of these conditions in racing sled dogs and to attempt to define a causative etiology. The mushing community has been strongly suspicious of an infectious etiology for the occurrence of diarrhea, with recent concern focused on Clostridium spp. and leading to inappropriate use […]
03259-A: Screening for Genetic Variants Using Whole Exome Sequencing in Dogs with Protein-losing Enteropathy
Canine protein-losing enteropathy (PLE) is a life-threatening syndrome characterized by loss of protein in the feces due to disease of the small intestine. The exact mechanisms that lead to protein loss are not well understood and approximately 50% of affected dogs die from their disease. Recently, genetic testing has led to the discovery of new […]
03140: Efficacy and Tolerability of Gelatin Tannate (Tasectan®) in Canine parvovirus-infected Dogs
Canine parvovirus (CPV) infection causes severe enteritis in young dogs, with massive intestinal mucosal damage secondary to infection of replicating enterocytes. The resultant breach in intestinal-blood barrier might lead to endotoxemia and bacterial translocation, which if left untreated, leads to fatality rates approximating 91%. Early supportive treatment improves survival rates up to 96% but involves […]
00270-A: In Vitro Immunosuppressive Effects of Metronidazole on Canine Lymphocytes
Immunosuppressive drugs are commonly administered to human and veterinary patients to control immune-mediated inflammatory diseases. Administration of a combination of immunomodulatory drugs with different mechanisms of action should result in more effective immunosuppression and fewer drug-induced adverse effects. Anecdotal evidence supports the use of corticosteroids, sulfasalazine, and metranidazole in the therapy of human and canine […]
00870-A: Analysis of Pancreatic Acinar Atrophy in the German Shepherd Dog Using the SNP Array
Pancreatic acinar atrophy (PAA) is a digestive disorder observed primarily in the German Shepherd Dog (GSD). Presently, there are no methods to diagnose the disease prior to the onset of clinical symptoms, which include maldigestion, weight loss, and loose stools. Diagnosis of EPI is achieved by measurement of serum canine trypsin-like immunoreactivity (cTLI), with severely […]
01609: Use of Probiotic to Reduce the Symptoms of Inflammatory Bowel Disease
Idiopathic inflammatory bowel disease (IBD) is a common cause of chronic gastrointestinal disease in dogs. Accumulating evidence in human IBD and animal models suggests that imbalances in composition of the intestinal microbiota contribute to the pathogenesis of chronic intestinal inflammation. Recent studies have also shown that dogs with IBD have distinctly different duodenal microbial communities […]
00803-A: Toll-Like Receptors in Dogs And Their Role in Intestinal Inflammation
Inflammatory bowel disease (IBD) is a common cause of chronic vomiting and diarrhea in dogs, but its true incidence is not known. The underlying etiology is unknown, and comparisons have been made with similar human conditions. Although IBD can potentially occur in any dog breed, certain predispositions are recognized, such as lymphocytic-plasmacytic enteritis in German […]
00945: Mucosal Gene Expression Profiles in Canine Inflammatory Bowel Disease
Canine inflammatory bowel disease (IBD) is a chronic intestinal disorder likely resulting from the interaction between genes and environmental factors. We propose to utilize unique molecular biology tools to: (1) identify key genetic factors contributing to disease expression, (2) characterize gene expression profiles which may predict responsiveness to specific therapies, and (3) provide the framework […]
03158: The Associations between Circulating Saturated and Unsaturated Fatty Acids and the Fecal Microbiome and Metabolome with the Development and Severity of Canine Acute Pancreatitis
Pancreatitis, inflammation of the pancreas, occurs when safety mechanisms responsible for preventing intra-pancreatic activation of digestive enzymes fail, allowing pancreatic auto-digestion. Acute pancreatitis (AP) is common in dogs, and may progress into a severe, fatal disease. Increased serum fatty acid (sFAs) concentrations (‘hyperlipidemia’) and obesity are risk factors for AP; however, additional factors determine AP […]