0001633: Identification of a Genetic Marker for Pancreatic Acinar Atrophy Causing Exocrine Pancreatic Insufficiency in the German Shepherd Dog
Exocrine pancreatic insufficiency (EPI), a disease marked by chronic diarrhea and weight loss, is most commonly seen in German Shepherd Dogs. This condition is almost exclusively caused by atrophy of pancreatic cells that secrete digestive enzymes. This disease process is termed pancreatic acinar atrophy (PAA). Previous research has indicated that PAA is inherited in the […]
01445: Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing
Granulomatous colitis (GC) is a severe inflammatory bowel disease (IBD), typically diagnosed in Boxer dogs younger than four years of age. Affected dogs present with hemorrhagic diarrhea, often progressing to weight loss, anemia, hypoalbuminemia, and chronic debilitation. Recent studies have identified invasive Escherichia coli within macrophages in diseased intestinal tissue, and eradication of E. coli […]
01227-A: Specificity and Sensitivity of the Pancreatic Lipase Immunoreactivity (SPEC cPL) Test for the Diagnosis of Canine Pancreatitis
Pancreatitis is a common and debilitating disease in dogs. The non-invasive diagnosis of canine pancreatitis remains challenging despite the advent of abdominal ultrasound and pancreas-specific blood tests. The pancreas-lipase immunoreactivity blood test was recently modified to address these concerns; however, the interpretation of abnormal pancreas-lipase test results in the absence of other supportive signs or […]
0001873: Sequential Clinical Evaluation, Mode of Inheritance, and Therapeutic Trial of Protein-Losing Enteropathy and Nephropathy in Soft Coated Wheaten Terriers
Soft Coated Wheaten Terriers (SCWT) are at risk for protein wasting diseases of the kidneys and intestines. Clinical Signs of this disease vary but can be quite severe, including death. We have demonstrated that the disease is associated with food allergies. We propose to continue the evaluation of a colony of SCWT and SCWT-cross dogs […]
0002232: Cricopharyngeal Dysphagia in the Golden Retriever
Cricopharyngeal Dysphagia is a swallowing disorder in dogs that is apparent at the time of weaning. It may result in failure to thrive, regurgitation, nasal discharge, pneumonia or even death resulting from recurrent pneumonia. Cricopharyngeal dysphagia has been described in several dog breeds and is suspected to be an autosomal recessive disease in these breeds. […]
01937-B: Evaluating the Complex Genetic Basis of Bloat
Gastric dilatation and volvulus (GDV), or bloat, is a common condition in large and giant breed dogs with an unacceptably high morbidity and mortality rate. Due to the importance of GDV in many dog breeds, several previous studies have investigated potential risk factors for the development of GDV. It is known that there is no […]
00454: Analysis of a Candidate Gene for Pancreatic Acinar Atrophy in the German Shepherd Dog
Although pancreatic acinar atrophy is primarily a disease found in the German Shepherd Dog, it is also diagnosed in other breeds such as the Rough Collie and Dachshund. Diagnosis is usually not made until later in life, therefore, affected and carrier dogs are unknowingly bred. When diagnosed, the current 3treatment is enzyme therapy, which has […]
02742-A: Assessing Microvasculature for Intestinal Viability in Obstructed Small Intestines and Effects of Resection and Anastomosis Techniques
Intestinal foreign body ingestion is one of the most common causes for emergency surgery in dogs. Frequently, the foreign material causes damage to the intestines requiring surgical removal (resection) of the dead portion of intestine and surgical connection or re-attachment of the remaining intestine ends (anastomosis). At present, assessment of the need to resect and […]
00871-A: Canine Anal Furunculosis
We have previously identified a gene associated with Anal Furunculosis (AF) in a region of the genome that is rich in immune genes. We have now performed a whole genome scan comparing 24 German Shepherd dogs having AF with 36 unaffected control dogs, which has revealed 46 SNPs that are significantly associated with AF, and […]
01935-B: Abnormalities in the Stomach’s Ability to Contract Predisposes Large-Breed Dogs to Bloat
Gastric dilatation-volvulus (GDV), or bloat, is a devastating disease common in large and giant-breed dogs. Occurring most frequently in older dogs with a close relative who has also suffered the condition, the stomach becomes both displaced and distended with air. Without emergency medical stabilization and surgical intervention, affected dogs quickly experience shock, damage to the […]