This research will open a new perspective in canine autoimmune diseases if, similar to humans, a genetic correlation between affected animals and certain FcR-alleles are identified. With the established Fc-receptor primer set, screening of other autoimmune disease with a genetic background will be possible. If our experimental approach is successful, Cocker Spaniel and Irish Red Setter breeders will have a genetic test to identify dogs with a predisposition for immune-mediated diseases. Furthermore, for other dog breeds, a genetic testing might be possible because of a high identity of relevant genes.