The goal of this study is to identify the molecular genetic case for cystinuria in Irish Terriers. Preliminary data was obtained from DNA samples of Irish Terriers affected with cystinuria. The investigators generated and analyzed a whole genome sequence (WGS) from an affected Irish Terrier; however, no variants in cystinuria-associated genes were identified. Using additional dogs and WGS, the investigators will look for rare genetic variants in affected dogs using latest technologies, including an Oxford Nanopore sequencer to effectively detect potentially causal sequence variants.

Funding for the research is provided through the collaborative efforts and generosity of the Irish Terrier Club of America. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration and scientific progress.