02500: Immune Targeting of the V600E B-Raf Neoantigen in Canine Urothelial Carcinoma
Bladder cancer or urothelial carcinoma (UC) affects approximately 40,000 dogs per year in the US with specific breeds including Scottish Terriers, West Highland White Terriers, Shetland Sheepdogs, Beagles, and Parson Russell Terriers being over-represented. Affected dogs usually display lower urinary tract clinical signs including bloody urine, frequent urination, difficulty and pain on urinating, and urinary […]
01591: Identification of the Genes That Confer Risk for Atopic Dermatitis
186 WHWTs (97 affected and 89 normal) were genotyped on the high density Illumina SNP chip that gives very good coverage of the whole genome. Data from these dogs was used to perform association studies to determine whether there was a significant association between affected phenotype (clinical signs) and a particular chromosomal region. These analyses […]
0195: Characterization of the Clinical Features of Idiopathic Pulmonary Fibrosis in the West Highland White Terrier
A chronic respiratory condition has been noted for some time in West Highland White Terriers, and typically affects middle to old-aged dogs resulting in reduced exercise ability, respiratory difficulty and coughing. Eventually the condition results in respiratory failure and the dogs have to be euthanized. The condition develops slowly and consequently the changes are often […]
02699: The Pathologic Link between Lung and Gut: Diagnosis of Aerodigestive Disorders in Dogs
Chronic unintentional inhalation (aspiration) of small amounts of gastrointestinal contents into the respiratory tract can cause or worsen respiratory disease in dogs. Gastroesophageal reflux (GER) is reported in up to 90% of people with certain respiratory diseases but is under-recognized and therefore, not treated in dogs in large part because they cannot report signs of […]
00572-A: Heritability of Atopic Dermatitis in West Highland White Terriers
In dogs, atopic dermatitis (AD) is a very common chronic allergic skin disease that results in severe itching and skin lesions following self-trauma, impairing the quality of life of affected dogs. Atopic dermatitis has a high frequency of occurrence in several dog breeds, and it is especially common in West Highland White Terriers. We intend […]
02802: Clinical Trial of Prevotella histicola Supplementation to Ameliorate Meningoencephalomyelitis of Unknown Origin (MUO)
Meningoencephalomyelitis of unknown origin (MUO), also known by a number of other abbreviations such as MUE, MUA and, sometimes, GME (granulomatous meningoencephalomyelitis), is the name given to a group of closely-related inflammatory diseases of the brain and spinal cord. These conditions are common, about 25% or more of the neurologic cases treated by veterinary neurologists, […]
02363-A: Platelet Function in Dogs with Chronic Liver Disease
Chronic liver disease is common among adult dogs with numerous breeds being predisposed. Liver biopsy is usually required to identify the underlying cause of liver disease in these patients, and is often recommended to monitor response to treatment. Because dogs with liver disease have abnormal clotting activity, bleeding is a substantial risk of biopsy. Routine […]
02475-A: Effect of Periodontal Treatment on Glycemic Control in Canine Diabetic Patients: A Prospective, Clinical Study
Diabetes mellitus (DM) is a common endocrine disorder in dogs, with a strong breed disposition. The disease is associated with significant morbidity and death when left untreated, and tight control of blood glucose levels is crucial in avoiding the harmful effects of long-standing hyperglycemia. Insulin administration, appropriate diet, and treatment of concurrent diseases which interfere […]
02343-A: Recognizing and Removing Lipemic Interferences for Accurate Laboratory Testing
Grant Status: Closed Grant Amount: $9,113 Unity Jeffery, VetMB; Texas A&M University May 1, 2017 – April 30, 2018 Sponsor(s): Breed(s): -All Dogs Research Program Area: Blood Disorders Donate to Support this Research Program Area Project Summary Over thirty percent of Miniature Schnauzers have primary hyperlipidemia, a disease in which fats (also termed lipids) are […]
Ripples in the Water – Chlorination and Cancer Risk in Dogs
Introduction Bladder cancer affects tens of thousands of dogs in the United States each year, with certain breeds like the Scottish Terrier, West Highland White Terrier, and Shetland Sheepdog being particularly susceptible. This suggests a genetic influence on cancer risk, but environmental factors also play a large role in triggering this type of cancer. We […]