01889-Ga: Innovations in Prevention, Diagnosis, and Treatment of Cancer – Goldens Lead the Way
Lymphoma and hemangiosarcoma are major health problems in Golden Retrievers, causing both suffering and premature death. Through ongoing collaboration, Drs. Jaime Modiano, Matthew Breen, and Kerstin Lindblad-Toh have identified several regions of the genome that contain genetic heritable risk factors for lymphoma and hemangiosarcoma in Golden Retrievers. They have tumor-specific mutations that occur recurrently in […]
02637-A: Reducing Misdiagnosis of Immune-Mediated Hemolytic Anemia
Immune-mediated hemolytic anemia (IMHA) is a common life-threatening disease requiring intensive and expensive therapy. Veterinarians often diagnose IMHA using a saline agglutination test. This test aims to distinguish red cell aggregates induced by antibodies from non-immune-mediated red cell interactions. However, this test can produce up to 20% false positives, thus requiring an improved test. One […]
01762: Use of Plasma-Derived Growth Factors to Heal Cruciate Rupture
Over the last year, we have completed patient recruitment and recheck examinations for this study. We enrolled 29 dogs in this prospective clinical trial, 27 of which completed the study. One dog was lost to follow up and one dog died before completion of the study due to unrelated disease. All dogs enrolled in the […]
02988: Plasminogen-activator Inhibitor-1 (PAI-1) and Impaired Fibrinolysis in Immune-Mediated Hemolytic Anemia
Immune-mediated hemolytic anemia (IMHA) is a common, and often life-threatening, blood disorder in dogs where the dog’s immune system attacks its own red blood cells, leading to a severe anemia that is treated with immunosuppressive drugs. However, affected dogs suffer from more than just anemia. They also have over-active clotting systems that lead to abnormal […]
03030-A: Evaluation of Serum C-reactive Protein as a Noninvasive Biomarker of Inflammation and Disease Severity in Dogs with Gallbladder Mucocele
In the last 20 years a condition called gallbladder mucocele has emerged as a very common disease of the liver in dogs. This disease is associated with the accumulation of congealed bile in the gallbladder that subsequently cannot empty properly into the intestine. The result of this is often irreversible damage to the gallbladder wall […]
02515-A: Investigating the Role of Interleukin-17-producing Cells in the Pathophysiology of Canine Immune Mediated Hemolytic Anemia
Canine primary immune-mediated hemolytic anemia (IMHA) is an acute and severe disease of dogs, with a mortality rate ranging up to 70%. IMHA is caused when the immune system produces abnormal antibodies that attack and destroy the dog?s own red blood cells. It is not known how or why these abnormal antibodies form in the […]
02336: Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels
Glaucoma is a leading cause of irreversible blindness and globe removal (enucleation) in dogs. Primary angle closure glaucoma (PACG) is the most common form of glaucoma in dogs whereby acute blockage of the iridocorneal angle leads to a rapid increase in intraocular pressure. Consequently, PACG is painful, demands immediate medical attention, and often causes incurable […]
01678-A: Apoptosis — not just for Nucleated Cells: the Contribution of Programmed Cell Death to Red Cell Destruction in Immune-Mediated Hemolytic Anemia
Red blood cells (RBCs) are biconcave cells that circulate in the blood stream and provide oxygen to all tissues of the body. The number and lifespan of circulating RBCs are tightly regulated. “Old” RBCs undergo alterations that result in their recognition and removal from circulation by cells in the spleen (macrophages), whereas replacement RBCs are […]
02343-A: Recognizing and Removing Lipemic Interferences for Accurate Laboratory Testing
Grant Status: Closed Grant Amount: $9,113 Unity Jeffery, VetMB; Texas A&M University May 1, 2017 – April 30, 2018 Sponsor(s): Breed(s): -All Dogs Research Program Area: Blood Disorders Donate to Support this Research Program Area Project Summary Over thirty percent of Miniature Schnauzers have primary hyperlipidemia, a disease in which fats (also termed lipids) are […]
Exploring Genetic Causes of Glaucoma in the American Cocker Spaniel
Glaucoma is a group of eye diseases that damage the optic nerve and ultimately result in irreversible vision loss. Primary angle closure glaucoma (PACG) is the most common form of glaucoma in dogs. It is caused by blockage of the ‘drain’ between the iris (the colored part of the eye) and cornea (the transparent surface […]