03367: How genetics, environmental exposures, and the enteric nervous system influence gallbladder mucocele formation in dogs.
Mucocele formation is the most common gallbladder disease in dogs. The disease targets purebred dogs resulting in accumulation of thick and dehydrated mucus in the gallbladder which leads to biliary tract obstruction or rupture. Even with surgery to remove the gallbladder, 17% of dogs do not survive. Our long-term goal is to determine the cause […]
00582-A: Identification of Canine Microsatellites Associated with Genes Known to Cause Inherited Cataract Conditions in Humans
Cataract, an opacity of the lens, is very common in the dog and is a leading cause of blindness. Although cataracts can have a variety of causes, such as metabolic disease, senile changes, trauma, nutritional deficiencies and radiation therapy, hereditary cataracts (HC) are the most common form of cataract in dogs and are believed to […]
01633: Novel Therapy for Melanoma, Lymphoma, Meningioma and Nephroblastoma
Spontaneous melanoma strikes an estimated 50,000 dogs each year. Even with aggressive treatment, the median survival time is < 1 year. Dr. Wilson's research group has identified a new class of drugs, S100B inhibitors, which prevent the growth of canine/human melanoma cells as well as in vivo murine tumors. Two of these inhibitors, pentamidine and […]
02536-MOU: Immunoprofiling to Combat Canine Immune Thrombocytopenia
Autoimmune disease develops in dogs when their immune system destroys normal healthy cells in the body. Immune thrombocytopenia (ITP) is a serious bleeding disorder that results from immune destruction of platelets, small blood cells that play a critical role in preventing bruising and bleeding after injury. Old English Sheepdogs and Cocker Spaniels appear to have […]
01268: Investigation to identify genes associated with canine immune-mediated haemolytic anaemia
Grant Status: Closed Grant Amount: $68,339.56 Lorna J. Kennedy, PhD; University of Manchester January 1, 2010 – December 31, 2011 Sponsor(s): Australian Terrier Club of America, Border Terrier Club of America, Chihuahua Club of America, Miniature Pinscher Club of America, Inc., Orthopedic Foundation for Animals, Parson Russell Terrier Association of America, Pug Dog Club of […]
01390-A: The Use of Mycophenolate in the Treatment of Primary Immune Mediated Hemolytic Anemia
Grant Status: Closed Grant Amount: $1,693 Laura West, DVM; Veterinary Specialty Hospital of San Diego April 1, 2010 – September 30, 2011 Sponsor(s): Danny’s Fund, Joe & Carla Sanchez of Southport Mastiffs, Mastiff Club of America, Mastiff Club of America Charitable Trust Breed(s): English Springer Spaniel, Collie, Cocker Spaniel, Old English Sheepdog, Miniature Poodle, Standard […]
03143: Causative Role of Xenobiotic Exposures in Canine Gallbladder Mucocele Formation
Mucocele formation is the most common gallbladder disease to afflict dogs. Despite the best surgical care, 17% will not survive. Retrospective studies alone report numbers of affected dogs in the thousands and over 80 publications have now addressed this specific disease. We don’t know what causes mucocele formation and have no way to predict, prevent, […]
01689-A: Increasing the Effectiveness of Radiation Therapy in Treatment of Mast Cell Tumors
Canine mast cell tumors are the most common cutaneous malignant tumors in dogs. Histologic grades, I, II, and III, provide very useful information because they are indicative of a patient’s prognosis. Treatment options depend on negative prognostic factors, but in general surgery and radiation therapy are very effective. Chemotherapy could be applied if the patient […]
01031-A: Determination of Target Antigens in Canine Primary Immune-Mediated Hemolytic Anemia
Canine primary immune-mediated hemolytic anemia (IMHA) is a serious illness which involves attack of red cells by the patient’s own immune system. The result is severe anemia. Currently, it is not known what causes or triggers the patient’s immune system to turn against its own red blood cells. Numerous scientific reports indicate a breed predilection: […]
02920: Continued Investigation into Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
Canine mammary gland tumors (CMT) are the most common malignancies in intact female dogs with the resulting morbidity and premature death having a profound impact on a large number of dogs, their owners and the veterinarians that treat them. While genetic alterations within tumor cells can promote their uncontrolled growth and ability to spread to […]