01592: Investigation into the Genetics of Scottie Cramp: Sequencing of Associated Chromosomal Regions
Scottie Cramp is an episodic disorder of Scottish Terriers that produces a dramatic increase in muscle tone with excitement or exercise. The cause of the disease is unknown, although pharmacologic studies suggest that abnormal signaling between neurons plays a role. The disease is hereditary and is transmitted by an autosomal recessive trait. As a result, […]
02162-MOU: Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog
Chiari-like malformations and syringomyelia (CM/SM) are a common problem in Cavalier King Charles Spaniels (CKCS) causing severe neuropathic pain. The morphometry of the skull has been examined in detail and the development of clinical signs and syringomyelia has been correlated to reduced caudal fossa to cranial cavity volume ratios and stenosis of the jugular foramen […]
02649: Three-dimensional Echocardiographic Determinants of the Age of Onset of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels
Myxomatous mitral valve disease (MMVD) represents a major health issue in Cavalier King Charles Spaniels (CKCSs). The disease appears at an earlier age, compared to other breeds, and has a genetic, heritable basis. The cause of the disease is unknown, but the role of altered stresses on the mitral valve (MV) has been proposed as […]
02143-A: Development of a Novel Treatment for Intervertebral Disc Disease
Grant Status: Closed Grant Amount: $11,903 Gordon S. Mitchell; University of Wisconsin, Madison August 1, 2014 – January 31, 2016 Sponsor(s): Clumber Spaniel Health Foundation Breed(s): Dachshund Research Program Area: Neurology Donate to Support this Research Program Area Project Summary Subject recruitment was initiated upon receiving funding. Potential study subjects were identified through the electronic […]
02475-A: Effect of Periodontal Treatment on Glycemic Control in Canine Diabetic Patients: A Prospective, Clinical Study
Diabetes mellitus (DM) is a common endocrine disorder in dogs, with a strong breed disposition. The disease is associated with significant morbidity and death when left untreated, and tight control of blood glucose levels is crucial in avoiding the harmful effects of long-standing hyperglycemia. Insulin administration, appropriate diet, and treatment of concurrent diseases which interfere […]
03101-A: Enhancing Autophagy to Control Canine Myxomatous Mitral Valve Disease
Development of novel treatments to control degenerative diseases requires understanding of their molecular biology. Myxomatous mitral valve disease (MMVD) is one such disease, is the most important chronic degenerative cardiovascular disease of the dog, with no treatments to prevent, control or reverse valve pathology. In our laboratory we have shown important changes in the mechanisms […]
02792-A: Do Dogs Get Temporal Lobe Epilepsy? Clinical Signs, Magnetic Resonance Imaging and Pathological Findings in Epileptic Dogs
Thirty percent of dogs with idiopathic epilepsy have poor seizure control and are considered by their caregivers to have a poor quality of life despite appropriate medical therapy. Temporal lobe epilepsy (TLE) is the most common type of epilepsy in humans, and has been well described in other species, including cats. Many epileptic dogs have […]