00423: Evaluation of Objective Structural and Functional Measurements for Predicting Clinical Disease Progression and Assessing Treatment in Cavalier King Charles Spaniels with Caudal Occipital Malformation Syndrome
There has been growing concern in the Cavalier King Charles Spaniel community in recent years regarding a congenital malformation referred to as “”Caudal Occipital Malformation Syndrome.”” This is a condition in which the skull is too small to house the normal brain structures. The crowding results in fluid buildup within the brain (termed hydrocephalus) and […]
00806-A: Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease
Mitral valve endocardiosis (MVE) is the single most common acquired cardiac disease of dogs and is characterized by myxomatous degeneration of the mitral heart valve. The disease is highly age-related and breed specific, but can be seen in any aged dog (Beardow & Buchanan, 1993). Much is known about the clinical features of canine MVE, […]
0002244: Quantitative, Functional and Morphologic Characterization of Platelets in the Cavalier King Charles Spaniel
Platelets are cells that circulate in the blood and function in blood clotting. Unusually large platelets and slightly low platelet counts have been reported in Cavalier King Charles Spaniels (CKCS), estimated to affect up to 30 percent of the breed. However, whether these abnormalities are inherited or pose a problem in the normal functioning of […]
01413: Investigation into the Genetics of Scottie Cramp: a Genome-Wide Association Study
Grant Status: Closed Grant Amount: $45,320.62 Natasha J Olby, VetMB PhD; North Carolina State University January 1, 2011 – March 31, 2012 Sponsor(s): Airedale Terrier Club of America, American Belgian Tervuren Club, Inc., English Springer Spaniel Field Trial Association, Flat-Coated Retriever Foundation, German Shorthaired Pointer Club of America, German Wirehaired Pointer Club of America, Golden […]
02332-A: Identification of Mutations for Primary Lens Luxation in Multiple Dog Breeds
Primary lens luxation (PLL) is a painful inherited disease that affects many breeds of dog. A mutation in the gene ADAMTS17 has been identified that causes PLL in at least 20 breeds and DNA tests are available for these breeds. Different mutations in ADAMTS17 are also known to cause a different disease, primary open angle […]
02955: Towards Precision Medicine for Canine Cardiac Disease: A Genomic and Machine-Learning Approach to Prediction of Risk and Outcomes in Canine Myxomatous Mitral Valve Disease
Myxomatous mitral valve disease (MMVD) is the most common cause of heart disease in adult dogs, affecting millions of dogs worldwide. Small- and medium-sized dogs, especially Cavalier King Charles Spaniels, Dachshunds, Poodles, and Yorkshire Terriers, are predisposed to MMVD, suggesting that the disease has a genetic basis. MMVD typically progresses slowly, over several years, eventually […]
01866-A: Enhancing Treatment of Mitral Valve Disease through the Identification of Biological Markers of Disease
Heart disease, specifically chronic valvular disease (CVD), is a common disease in aging dogs. All dogs can develop this disease, but small breed dogs and especially the Cavalier King Charles Spaniel have a higher risk. Typically, all Cavaliers over the age of 10 years of age are affected. The disease is easy to diagnose, because […]
00954: Identification of Genes Causing Chiari I Malformation with Syringomelia in the Cavalier King Charles Spaniel
Chiari-like malformation (CM) is a deformity that occurs in the region where the brain joins the spinal cord and that is present at birth. The lower portions of the brain protrude into the vertebral canal causing a variety of clinical signs. CM is often associated with syringomyelia (SM), which describes an abnormal collection of cerebral […]
03279: Understanding the Immune Landscape of Canine Myxomatous Mitral Valve Disease and the Role of Inflammation in Disease Pathogenesis
Canine myxomatous mitral valve disease (MMVD) is the most common acquired heart disease and the most frequent cause of heart failure in dogs, resulting in difficulty breathing and eventual death. This is an aging-related disease affecting many older dogs, especially small breed dogs such as the Cavalier King Charles Spaniel and Dachshund. Once in heart […]
01529-A: Platelet, myocardial, and valvular serotonin concentrations in healthy dogs and dogs with mitral valve disease
In humans, increased serotonin (5-HT) signaling causes valvular disease with pathologic characteristics that are very similar to canine mitral valve disease (MVD). We have previously shown that serum 5HT concentrations are elevated in dogs with MVD as well as in dogs that are at high risk for development of disease. Our findings specifically identified the […]