02081-A: Integrating Cutting Edge Science with Scientific Training to Defeat Hemangiosarcoma
Canine hemangiosarcoma (HSA) is an intractable disease with no warning signs and no effective treatments. Contemporary research is overturning long-held, yet incorrect assumptions about its origins and biological behavior. One approach to accelerate progress is to bring young, talented scientists with no deep-held biases into the field and allow them to evaluate data with a […]
02171-MOU: Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment
Canine histiocytic sarcoma (HS) is a highly aggressive cancer that affects Bernese Mountain Dogs (BMD), with a particularly high prevalence rate that ranges from 15 to 25% of the population. The current treatment options for HS are based on the administration of conventional chemotherapeutic drugs, to which dogs respond poorly and only for a short […]
01557: Narrowing the Search for the Genetic Basis of Histiocytic Malignancies
In a previous study (CHF-760) Dr. Breen demonstrated that canine histiocytic malignancies (HMs) present with a high degree of DNA copy number alterations. His research group identified several aberrant regions of the genome that are highly recurrent between cases, suggesting that such regions are associated causally with the malignant process. Understanding the biology of genes […]
02093-MOU: Sequencing Histiocytic Sarcoma (HS) loci identified by Genetic Association studies in the Bernese Mountain Dog (BMD)
Histiocytic sarcoma (HS) occur at a high incidence in few breeds, specifically in Bernese Mountain Dogs (BMD), Rottweilers and Retrievers. Dr. Andre and her team have previously identified main genomic regions associated with HS in the BMD breed. The validations of these regions on over 1000 French BMDs allowed them to develop a first genetic […]
0001440: Evaluating the Causative Mutation for von Willebrand’s Disease in the Doberman Pinscher and Its Possible Role in Other Breeds
This research was responsible for the development of five genetic tests for von Willebrand’s disease (vWD). vWD is an inherited bleeding disorder that is seen frequently in Doberman Pinschers. In Dobermans, it is autosomal recessive (affected dogs receive one mutated gene from each parent). Researchers determined that Dobermans have a very high frequency of this […]
00935A: Positional Cloning of Two Genes for Malignant Histiocytosis (MH) in the Bernese Mountain Dog
While rare in the general canine population, histiocytic cancers occur at a high incidence in several breeds, most notably Bernese mountain dogs (BMD) and flat-coated retrievers (FCR). Primarily through the generosity of grants funded by the AKC Canine Health Foundation, the investigators have identified two genomic regions that associate with histiocytic cancer in the BMD […]
03228: Identification of Tumor-Specific Proteins for Targeted Therapy in Solid and Disseminated Histiocytic Sarcoma
Canine Histiocytic Sarcoma (HS) is a frequent and fatal neoplastic disease that affects dogs from different breeds, with a particular predisposition in Bernese Mountain Dogs and Flat-Coated Retrievers. As currently available therapies are unable to provide reliable and sustainable control of the disease, novel approaches are urgently needed to help affected patients. Novel approaches, such […]
01762: Use of Plasma-Derived Growth Factors to Heal Cruciate Rupture
Over the last year, we have completed patient recruitment and recheck examinations for this study. We enrolled 29 dogs in this prospective clinical trial, 27 of which completed the study. One dog was lost to follow up and one dog died before completion of the study due to unrelated disease. All dogs enrolled in the […]
01410B: Positional Cloning of Histiocytic Sarcoma (HS) in the Bernese Mountain Dog (BMD) and Flat Coated Retriever (Part B – See also 01410A)
While rare in the general canine population, histiocytic cancers occur at a high rate in several breeds, most notably Bernese mountain dogs (BMD) and flat-coated retrievers (FCR). We have identified two genomic regions that associate with histiocytic cancer in the BMD and two different regions in the FCR. We propose to identify the specific DNA […]
01601: Identifying the Genetic Cause of Fatal Neonatal Liver Disease
Intrahepatic portosystemic shunt (IHPSS) is a liver disease caused by a failure to close a vessel that regulates blood flow from the placenta to vital organs like the lungs and heart during fetal development. This vessel should close within a few days after birth so that the liver is no longer bypassed by the vital […]