00705-A: Characterization of Fluorine-18-Fluorodeoxyglucose Uptake in Dogs with Cutaneous Mast Cell Tumor and Malignant Lymphoma
“The University of Tennessee’s College of Veterinary Medicine (UTCVM) has a unique opportunity for collaboration with the Cancer Imaging and Tracer Development Research Program (CITDRP) at the University of Tennessee Medical Center. The UTCVM has established a strong collaboration with the CITDRP for the benefit of human and veterinary patients. We will use PET imaging […]
00336B: Mapping of the Gene for Malignant Histiocytosis in the Bernese Mountain Dog
We are interested in finding the genes that predispose the Bernese Mountain Dog (BMD) to malignant histiocytosis (MH) for three reasons. First, we are interested in improving the health of this increasingly popular breed, which is severely affected by this deadly disease. Finding the underlying disease gene will lead to the development of genetic tests […]
02446: Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma
Several breeds of dog, including Retrievers, Bernese Mountain Dogs and Rottweilers, are known to present elevated risks of cancers including histiocytic sarcoma (HS), lymphoma, and hemangiosarcoma. HS may be misdiagnosed due to clinical presentation shared with these other cancers. Due to the aggressiveness of HS and its late diagnosis, there is no known effective treatment. […]
0002667: Cellular Genomics – Molecular Cytogenetic Investigation of Canine Soft Tissue Sarcomas
It has been established that non-random chromosome aberrations are characteristic of specific types of many different human cancers. The knowledge of such aberrations has identified areas of the human genome to be targeted for further research. In the dog the extent and identity of chromosome aberrations associated with specific cancers is still largely unknown. In […]
00935B: Positional Cloning of Two Genes for Malignant Histiocytosis (MH) in the Bernese Mountain Dog
Grant Status: Closed Grant Amount: $86,400 Catherine Andre, PhD; CNRS – University of Rennes September 1, 2008 – July 31, 2010 Sponsor(s): Golden Retriever Foundation Breed(s): Bernese Mountain Dog Research Program Area: Oncology Donate to Support this Research Program Area Project Summary While rare in the general canine population, histiocytic cancers occur at a high […]
01759: Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma
Grant Status: Closed Grant Amount: $233,914 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2013 – December 31, 2015 Sponsor(s): American Belgian Tervuren Club, Inc., American Bouvier des Flandres Club – Bouvier Health Foundation, American German Shepherd Dog Charitable Foundation, Inc., American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics […]
01429: Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma
Grant Status: Closed Grant Amount: $100,000 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2011 – June 30, 2013 Sponsor(s): American Bullmastiff Association, Boston Terrier Club of America, Briard Club of America Health & Education Trust, Flat-Coated Retriever Foundation, Golden Retriever Foundation, Plum Creek Kennel Club of Colorado, Rhodesian Ridgeback Club of the […]
00336A: Mapping of the Gene for Malignant Histiocytosis in the Bernese Mountain Dog
We are interested in finding the genes that predispose the Bernese Mountain Dog (BMD) to malignant histiocytosis (MH) for three reasons. First, we are interested in improving the health of this increasingly popular breed, which is severely affected by this deadly disease. Finding the underlying disease gene will lead to the development of genetic tests […]
01410A: Positional Cloning of Histiocytic Sarcoma (HS) in the Bernese Mountain Dog (BMD) and Flat Coated Retriever (Part A – See also 01410B)
Grant Status: Closed Grant Amount: $50,000 Elaine A Ostrander, PhD; National Human Genome Research Institute January 1, 2011 – December 31, 2011 Sponsor(s): American Bouvier des Flandres Club – Bouvier Health Foundation, American Bullmastiff Association, American German Shepherd Dog Charitable Foundation, Inc., American Miniature Schnauzer Club, Inc., Australian Shepherd Health & Genetics Institute, Australian Terrier […]
01585: Evaluating a Safer, Less Toxic Radiation Therapy in the Treatment of Lymphoma
Grant Status: Closed Grant Amount: $93,140 Michael A. Deveau, DVM, MS; Texas A&M Research Foundation January 1, 2012 – June 30, 2014 Sponsor(s): American Foxhound Club, American German Shepherd Dog Charitable Foundation, Inc., American Spaniel Club Foundation, Clumber Spaniel Club of America, English Setter Association of America, Inc., Keeshond Anonymous Fund, Pembroke Welsh Corgi Club […]