Hemangiosarcoma Research
The AKC Canine Health Foundation (CHF) funds research to better understand hemangiosarcoma, an aggressive cancer, with a focus on developing advanced diagnostics and more effective treatments.
Why We Focus on Hemangiosarcoma
Hemangiosarcoma is an aggressive and common cancer in dogs. It can develop in any tissue or organ, but most commonly affects the spleen, heart, and skin. Hemangiosarcoma is often referred to as the “silent killer” because tumors can remain undetected until they are in advanced stages, and even large tumors may not show visible signs in dogs. Unfortunately, current treatments have not significantly improved survival rates for dogs with this disease. By studying the biology, progression, and potential treatments for hemangiosarcoma, we aim to develop new diagnostic tools and therapies to help save the lives of affected dogs and improve their outcomes.
Research Grants
Hemangiosarcoma ● $67,731
03286: Single Nucleus RNA Sequencing of Canine Hemangiosarcoma – A Comparative Study of Splenic, Extra-Splenic, and Metastatic Tumor Profiling for Targeted Therapeutic Development
Breed(s): All Dogs
Researcher(s): Alexandre B Le Roux, DVM, MS, DECVDI, DACVR and Ronan Chaligné, PhD
Sponsor(s): Irish Setter Club of America Foundation, United States Australian Shepherd Foundation, Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $73,257
03187: Investigating Volatile Organic Compounds as Potential Markers of Canine Hemangiosarcoma by Trained Bio-detection Dogs
Breed(s): All Dogs
Researcher(s): Cynthia M. Otto, DVM, PhD
Sponsor(s): Golden Retriever Foundation, Irish Setter Club of America Foundation, Labrador Retriever Club, Inc., Scottish Terrier Club of America, Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $150,000
02759-T: Reprogramming the Tumor Immune Niche in Canine Hemangiosarcoma
Breed(s): German Shepherd Dog, Golden Retriever, Labrador Retriever, Portuguese Water Dog, Schnauzer
Researcher(s): Jong Hyuk Kim, DVM, PhD
Hemangiosarcoma ● $156,065
03011: A GD3 Nano-scaled Liposomal Cancer Vaccine Clinical Trial for Canine Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Rowan Milner, BVSc
Sponsor(s): American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics Institute, English Setter Association of America, Inc., German Shorthaired Pointer Club of America, Inc., Great Dane Club of America, Irish Setter Club of Milwaukee, Inc., Nespola Charitable Foundation, University of Florida, Versatility in Poodles, Inc., American Chesapeake Club Charitable Trust, Golden Retriever Foundation, Gordon Setter Club of America, Inc., Siberian Husky Club of America, Inc., Tibetan Terrier Club of America/Tibetan Terrier Health & Welfare Foundation, Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $170,087
03003: Suppression of Extracellular Glutamate Efflux & mGluR1 Signaling to Impede Canine Hemangiosarcoma Cell Growth
Breed(s): All Dogs
Researcher(s): Timothy Fan, DVM, PhD
Sponsor(s): American Spaniel Club Foundation, Bearded Collie Club of America, English Setter Association of America, Inc., German Shorthaired Pointer Club of America, Inc., Versatility in Poodles, Inc., American Chesapeake Club Charitable Trust, Collie Health Foundation, Golden Retriever Foundation, Irish Setter Club of America Foundation, Rottweiler Health Foundation, Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $348,559
02946: Towards Curative Outcomes in Canine Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Chand Khanna, DVM, PhD
Sponsor(s): Afghan Hound Club of America, Inc., American Wirehaired Pointing Griffon Association / Foundation, Australian Shepherd Health & Genetics Institute, Great Dane Club of America, Irish Setter Club of Milwaukee, Inc., Akita Club of America, Inc., Dalmatian Club of America Foundation, Inc., Irish Setter Club of America Foundation, National Beagle Club, Rottweiler Health Foundation, Scottish Terrier Club of America, United States Australian Shepherd Foundation, Vizsla Club of America Welfare Foundation, Westie Foundation of America, Inc.
Hemangiosarcoma ● $102,549
02942: Genome-wide Molecular Interrogation of Canine Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Scott Coonrod, PhD
Sponsor(s): Australian Shepherd Health & Genetics Institute, Bearded Collie Club of America, English Setter Association of America, Inc., National Beagle Club, United States Australian Shepherd Foundation
Hemangiosarcoma ● $11,718
02864-A: Luteinizing Hormone Receptor Activation in Canine Hemangiosarcoma Cells
Breed(s): All Dogs
Researcher(s): Michelle Kutzler, DVM, PhD
Sponsor(s): American Bouvier des Flandres Club – Bouvier Health Foundation, Great Pyrenees Club of America, Golden Retriever Foundation, Jeffrey Pepper, Westie Foundation of America, Inc.
Hemangiosarcoma ● $269,238
02806-MOU: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up
Breed(s): Boxer, Golden Retriever, Portuguese Water Dog
Researcher(s): Jaime F Modiano, VMD PhD
Sponsor(s): American Boxer Charitable Foundation, Golden Retriever Foundation, Portuguese Water Dog Foundation
Hemangiosarcoma ● $121,852.67
02759: Reprogramming the Tumor Immune Niche in Canine Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Jong Hyuk (Jon) Kim, DVM, PhD
Sponsor(s): American Bouvier des Flandres Club – Bouvier Health Foundation, Bedlington Terrier Club of America, Bedlington Terrier Wellness and Rescue Association, Inc., University of Minnesota, Irish Setter Club of America Foundation, Portuguese Water Dog Foundation, Siberian Husky Club of America, Inc., Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $15,000
02746-A: Evaluation of Serum miRNA as a Diagnostic Tool for Canine Splenic Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Janet Grimes, DVM, MS
Sponsor(s): Australian Shepherd Health & Genetics Institute, Golden Retriever Foundation, Irish Setter Club of America Foundation, National Beagle Club, Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $334,306
02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Erin B. Dickerson, PhD and Antonella Borgatti, DVM, MS
Sponsor(s): American Belgian Tervuren Club, Inc., American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics Institute, Bearded Collie Club of America, Briard Club of America/ BCA Health & Education Trust, Clumber Spaniel Health Foundation, English Setter Association of America, Inc., Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Irish Setter Club of Milwaukee, Inc., Old English Sheepdog Club of America, Rhodesian Ridgeback Charitable Foundation, Rhodesian Ridgeback Club of the United States, SCWTCA Endowment, Inc., University of Minnesota, Gordon Setter Club of America, Inc., Irish Setter Club of America Foundation, Labrador Retriever Club, Inc., Portuguese Water Dog Foundation, Rottweiler Health Foundation, Samoyed Club of America Education & Research Foundation, The Kennel Club of Philadelphia, United States Australian Shepherd Foundation, Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $168,857
02510-T: Identification of Novel Synthetic Lethal Partners to Optimize PI3K Targeted Therapies in Canine Hemangiosarcoma
Breed(s): All Dogs
Researcher(s): Cheryl A. London, DVM, PhD
Sponsor(s): Vizsla All Star Review, Vizsla Club of America, American Bouvier des Flandres Club – Bouvier Health Foundation, American German Shepherd Dog Charitable Foundation, Inc., Australian Shepherd Health & Genetics Institute, Briard Club of America/ BCA Health & Education Trust, Dachshund Club of America, Inc., French Bulldog Club of America, Irish Setter Club of Milwaukee, Inc., Leonberger Health Foundation, American Boxer Charitable Foundation, Gordon Setter Club of America, Inc., Irish Setter Club of America Foundation, Pembroke Welsh Corgi Club of America, Scottish Terrier Club of America, United States Australian Shepherd Foundation, Vizsla Club of America Welfare Foundation
Hemangiosarcoma, Tick-Borne Disease ● $219,026
02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations
Breed(s): All Dogs
Researcher(s): Edward B Breitschwerdt, DVM
Sponsor(s): Saluki Health Research, Inc., Vizsla All Star Review, Vizsla Club of America, Weimaraner Foundation Fund Corporation, American Bullmastiff Association, American Pointer Club, Australian Shepherd Health & Genetics Institute, Briard Club of America/ BCA Health & Education Trust, Clumber Spaniel Health Foundation, English Setter Association of America, Inc., French Bulldog Club of America, Irish Setter Club of Milwaukee, Inc., Leonberger Health Foundation, SCWTCA Endowment, Inc., Soft Coated Wheaten Terrier Club of America, Inc., Versatility in Poodles, Inc., American Bloodhound Club, American Boxer Charitable Foundation, Gordon Setter Club of America, Inc., Jeffrey Pepper, Portuguese Water Dog Foundation, Siberian Husky Club of America, Inc., Vizsla Club of America Welfare Foundation
Hemangiosarcoma ● $432,000
02234-MOU: A Novel Approach for Prevention of Canine Hemangiosarcoma
Breed(s): Boxer, Golden Retriever, Portuguese Water Dog
Researcher(s): Jaime F Modiano, VMD, PhD
Sponsor(s): Irish Setter Club of Milwaukee, Inc., American Boxer Charitable Foundation, Golden Retriever Foundation, Portuguese Water Dog Foundation
Join Us in Advancing
Canine Health
With over $3.8 million invested in hemangiosarcoma research, your support helps us fund critical studies that aim to improve the diagnosis and treatment of this devastating disease.
