01557: Narrowing the Search for the Genetic Basis of Histiocytic Malignancies
In a previous study (CHF-760) Dr. Breen demonstrated that canine histiocytic malignancies (HMs) present with a high degree of DNA copy number alterations. His research group identified several aberrant regions of the genome that are highly recurrent between cases, suggesting that such regions are associated causally with the malignant process. Understanding the biology of genes […]
01052-A: Whole Genome Association Mapping of Squamous Cell Carcinoma (SCC) of the Digit in the Standard Poodle
Squamous cell carcinoma (SCC) of the digit is a highly breed specific skin cancer with increased risk found in large black dogs, including the standard poodle, giant schnauzer and Gordon setter. This cancer is more aggressive than most SCCs with 80% of cases involving bone lysis and 5-13% recurring in multiple toes. When invasive, the […]
02405-A: Transcriptome Based Diagnostics in Canine Soft Tissue Sarcoma
Sarcomas are malignant cancers that can arise in any part of the body; however, in the dog, a subset referred to as soft tissue sarcomas account for 10-15% of all skin and subcutaneous cancers. Traditionally biopsy and subsequent histology have been the primary means of diagnosing these cancers. The histology is assigned to one of […]
02093-MOU: Sequencing Histiocytic Sarcoma (HS) loci identified by Genetic Association studies in the Bernese Mountain Dog (BMD)
Histiocytic sarcoma (HS) occur at a high incidence in few breeds, specifically in Bernese Mountain Dogs (BMD), Rottweilers and Retrievers. Dr. Andre and her team have previously identified main genomic regions associated with HS in the BMD breed. The validations of these regions on over 1000 French BMDs allowed them to develop a first genetic […]
01872-A: Using Ultrasound as a Cost Effective and Non-Invasive Technique for Early Diagnosis of Solid Tumors
This study was being conducted at the Louisiana State University School of Veterinary Medicine. We enrolled 20 dogs in the healthy group and 46 in the affected group to this date that corresponds to 80% of the intended number of affected dogs (60). The healthy dogs ranged in age from 1 to 11 years and […]
1093B-T: Positional Cloning of the Gene(s) for Gastric Cancer in the Chow Chow
Our work has documented an increased risk of gastric carcinoma (stomach cancer) in the Chow Chow as well as a number of other breeds including Akita, Belgian Sheepdog, Tervuren and Malinois, Bouvier, Eurasier, Irish Setter, Keeshond, Norwegian Elkhound, and the Scottish Terrier. In 2002, we initiated a database and sample repository for the study of […]
02920: Continued Investigation into Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
Canine mammary gland tumors (CMT) are the most common malignancies in intact female dogs with the resulting morbidity and premature death having a profound impact on a large number of dogs, their owners and the veterinarians that treat them. While genetic alterations within tumor cells can promote their uncontrolled growth and ability to spread to […]
01708-A: Validation of a general method for enrichment of canine cancer stem cells
Osteosarcoma, hemangiosarcoma, and glioblastoma multiforme are three types of incurable cancers that are responsible for reduced quality of life and significant mortality in dogs. The processes that control the clinical behavior of these tumors is not well understood, but recent research suggests that a specialized group of cells called “cancer stem cells” (or CSCs) might […]
01698-A: Immunohistochemical quantification of the transcobalamin II protein and receptor in naturally occurring canine tumors.
According to the National Cancer Institute, a dog is diagnosed with cancer every 5 seconds in the United States each year. Despite advances in research, only one drug is currently FDA-approved for treatment of cancer in dogs. Unfortunately, use of this drug is limited to certain tumor types, and is complicated by adverse side effects. […]
01929-A: Arginine Dependence: Identification of Cancer’s Achilles Heel
Arginine is a nonessential amino acid. This means that some normal cells in the body can make their own arginine and, once they make it, put it into the circulation for others cells of the body to use for such purposes as making proteins. Interestingly, it has been shown that many tumor cells cannot make […]