0002291: Molecular Genetic Causes for Canine Lens Luxation and Glaucoma
Heritable lens luxation, if not treated promptly, will induce secondary glaucoma. In addition, heritable primary glaucoma can cause secondary lens luxation. Since it is not always known whether lens luxation or glaucoma is the primary disease, we believe it is rational to study both diseases together. One or the other of these diseases is responsible […]
02572-MOU: Characterization of Retinal Phenotypes and their Association with RPGRIP1 and Modifiers in English Springer Spaniels
Advances in molecular techniques have led to the identification of nearly 30 gene mutations that cause inherited retinal diseases in dogs, often leading to loss of vision. While an insert in the RPGRIP1 gene has been linked to a blinding retinal disease first found in Dachshunds, this same mutation is very common in English Springer […]
00866-A: Phenotypic Characterization Using Electroretinography in Hereditary Retinal Degeneration of English Springer Spaniels
Progressive retinal atrophy (PRA) is a blinding disease that affects more than 100 canine breeds. We propose to characterize the disease in the English Springer Spaniel in order to prepare for future molecular genetic studies. For this we will use new portable electroretinography equipment (ERG) that can measure retinal function objectively. By using ERG, affected […]
02057: Identification of the Genetic Cause of Corneal Ulcers
Spontaneous chronic corneal epithelial defects (SCCEDs) describe an eye disorder characterized by chronic corneal ulcers that fail to undergo normal healing. The predilection of certain breeds suggests that SCCEDs is inherited. Affected dogs develop spontaneous corneal ulcers that are often exceptionally painful and persist for weeks to months. Most dogs require surgical therapy to heal […]
02952: Genetics of X-linked Progressive Retinal Atrophy in Greyhounds
Progressive retinal atrophy (PRA) is a group of heritable retinal diseases characterized by retinal degeneration in both eyes which progresses to blindness and for which no treatment exists. Most forms of PRA occur via an autosomal recessive form of inheritance with only a few X-linked PRAs reported due to degeneration of areas of the retina […]
02145-A: Prevention of Glaucoma and Goniodysgenesis through Genetic Profiling of Disease
Primary glaucoma is a painful and blinding disease associated with high pressure inside the eye. Glaucoma affects over 40 breeds of dogs worldwide, at least 1500 dogs in the UK each year and in the USA as many as 15,000 dogs per year could be affected. Treatment is usually unsuccessful and most affected dogs ultimately […]
02948-A: Effect of Glycemic Control on the Onset of Cataract Development in Diabetic Dogs
Diabetes mellitus is a common endocrine disorder in dogs. Its most common long-term complication is cataract formation, occurring in about half of the dogs within six months of diagnosis. Diabetic cataracts typically develop quickly, causing blindness and requiring expensive surgery to restore vision. It is generally assumed that tight control of blood glucose levels delays […]
02061: Emergence of Pigmentary Uveitis as a Potential Cause of Cataracts and Glaucoma
Pigmentary uveitis affects 10% of senior Golden Retrievers and frequently results in blindness due to cataracts and/or glaucoma. The pain of glaucoma often leads to removal of the eye. Currently there is no way to prevent or effectively treat pigmentary uveitis. Evidence strongly suggests pigmentary uveitisis an inherited disease: it is observed exclusively in the […]
Genetics of X-linked Progressive Retinal Atrophy in Greyhounds
Background and purpose This trial is being conducted to better characterize retinal degeneration syndrome in greyhounds with hopes of identifying the genetic components of this disease. Participation requirements Any Greyhounds diagnosed with retinal degeneration and their relatives. American Kennel Club registered Greyhounds, both males or females. Benefits and risks of participating Your pet will benefit […]
Exploring Genetic Causes of Glaucoma in the American Cocker Spaniel
Glaucoma is a group of eye diseases that damage the optic nerve and ultimately result in irreversible vision loss. Primary angle closure glaucoma (PACG) is the most common form of glaucoma in dogs. It is caused by blockage of the ‘drain’ between the iris (the colored part of the eye) and cornea (the transparent surface […]