Knowledge Hub
Access valuable information to help pet owners and veterinarians improve canine health and quality of life.
Lymphoma Research
The AKC Canine Health Foundation (CHF) supports critical research into understanding canine lymphoma.
Read MoreCanine Lymphoma
Lymphomas are cancers that arise from lymphocytes (white blood cells that fight disease). Normally, these cells travel through the body in the blood stream and in another network of thin “tubes” called lymph vessels, which interconnect organs of the lymphoid system (spleen, lymph nodes, thymus). Lymphocytes spend much of their time in these organs, where […]
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Epigenetic Biomarkers of B Cell Lymphoma
Introduction Lymphoma is one of the most common cancers in dogs, especially in breeds like Golden Retrievers. A new study funded by the AKC Canine Health Foundation reveals a breakthrough in understanding how this cancer develops at the molecular level (CHF Grant 01918-G: Discovery of Biomarkers to Detect Lymphoma Risk, Classify for Treatment, and Predict […]
Read More02309: Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma
Canine lymphoma is one of the most common cancers in dogs. While some breeds appear more at risk than others, all can be affected. Although it is often treatable, canine lymphoma can rarely be cured. A continued understanding of the mechanisms causing lymphoma in dogs and identification of novel therapies are needed to improve survival […]
Read More01545-A: Pilot Study to Assess Folate Receptor Expression in Canine High-Grade Multicentric Lymphoma
Multicentric lymphoma is a common cancer in pet dogs. Although multicentric lymphoma can typically be controlled for several months or longer with chemotherapy, it is ultimately lethal in most dogs. This research project was important in demonstrating that half (5 of 10) of dogs with multicentric lymphoma in a pilot study had marked uptake of […]
Read More00613: The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma
Grant Status: Closed Grant Amount: $113,929 Matthew Breen, PhD; North Carolina State University August 1, 2008 – July 31, 2011 Sponsor(s): Akita Club of America, Inc., American Bullmastiff Association, American Cavalier King Charles Spaniel Club Charitable Trust, Bernese Mountain Dog Club of America, Briard Club of America Health & Education Trust, Central New Jersey Hound […]
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Exploring Risk Factors for Canine Lymphoma
Introduction Lymphoma is one of the most common cancers in dogs, and Boxers are especially at risk. But why? With funding from CHF Grant 02318: Genetic and Environmental Risk for Lymphoma in Boxer Dogs, investigators at the University of Wisconsin, Madison set out to learn more about the combinations of genetic mutations and toxin exposures that […]
Read More02309-T: Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma
Canine lymphoma is one of the most common cancers in dogs. While some breeds appear more at risk than others, all can be affected. While often treatable, canine lymphoma can rarely be cured. A continued understanding of the mechanisms causing lymphoma in dogs and identification of novel therapies are needed to improve survival in dogs […]
Read More02998: Whole-Exome and Transcriptome Sequencing of Canine Small Cell B Cell Lymphoma and Comparative Analysis to Diffuse Large B Cell Lymphoma
Lymphoma is a common canine tumor. Diffuse large B cell lymphoma is the most common type of B cell lymphoma in dogs, but there are less common B cell lymphoma types that have aggressive behavior and little is known about the mechanisms driving these tumors. The goal of this study is to genetically characterize these […]
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