03020-T: Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs

CKD is commonly encountered in small animal practice, and affects up to 20% of all dogs. It is widely accepted that most dogs with stage II or greater CKD will progress to end-stage renal failure. Early detection of CKD and potential therapeutic targets in early stages of disease remains extremely challenging. Management of CKD in […]

01658: Early Detection of Chronic Kidney Disease to Prevent Kidney Damage

Chronic Kidney Disease (CKD) is a significant source of illness and death in dogs, affecting up to 15% of elderly individuals. Dysfunction of the kidney filtration system is most often the cause of CKD. Early treatment generally prolongs the lives of dogs with CKD, but timely detection can be difficult and the outcome for each […]

02807-MOU-T: Characterization of Renal Disease in Greyhound Dogs

Kidney disease is common in dogs, and some dog breeds seem to be more predisposed to development of kidney disease than other breeds. Greyhounds appear to be predisposed to proteinuric renal diseases; however, a complete characterization of the most common types of kidney diseases in this breed has not been performed to date, and potential […]

02110-A: Investigating the Effects of an Infusion of Fenoldopam on Kidney Function to Improve Outcomes of Acute Kidney Injury Patients

Acute kidney injury (AKI) is a devastating disease in canine patients. AKI represents a spectrum of disease characterized by a rapid loss of kidney function, resulting in impaired kidney filtration of metabolic waste products. Regardless of the inciting injury, the resulting kidney dysfunction causes increased serum kidney values and often decreased urine production. The resulting […]

02066: Identification of Novel Biomarkers and Therapeutic Targets for Chronic Kidney Disease in Dogs

Chronic kidney disease is a significant cause of illness and death in dogs. Early treatment can prolong the lives of dogs with chronic kidney disease, but timely detection can be difficult. The outcome for each patient using current, early non-invasive testing is unpredictable. Therefore, improvements in tests to detect kidney damage at an earlier stage […]

03026: Evaluation of the Efficacy of Antioxidant Treatment on Active Kidney Damage and Oxidative Stress

Chronic kidney disease (CKD) is associated with decreased kidney function and accumulation of toxins in the body. The irreversible disease is common in dogs and progressive in nature. Due to its rapid progression, the disease ultimately becomes fatal. Progression is associated with reduced quality of life and longevity. As CKD is incurable, slowing down its […]

02152: Translation of MicroRNA into an Early Diagnostic Test for Chronic Kidney Disease

Chronic kidney disease (CKD) is a significant cause of illness and death in dogs and is often due to glomerular diseases. Dogs with glomerular disease often have poor outcomes with standard therapy, and specific treatment recommendations are difficult without performing a kidney biopsy to determine the type of glomerular disease present, since treatment and outcome […]

02263-MOU: Characterization of Kidney Disease in Dalmatians

Chronic kidney disease is a significant progressive problem in dogs. Two different hereditary diseases of the urinary system are being studied in Dalmatian dogs: urinary stone formation (urolithiasis) and glomerular disease. These diseases cause distinct clinical signs: urolithiasis leads to urinary tract obstruction while glomerular disease results in protein loss into the urine (proteinuria). The […]

03281-MOU: Kidney Disease in Shetland Sheepdogs

Canine chronic kidney disease (CKD) is a common progressive disease in dogs and some breeds are predisposed to the development of kidney disease. Based on owner perception and published studies on canine CKD, Shetland Sheepdogs (Shelties) appear to be overrepresented, suggesting a hereditary nature of this disease in this breed. Current owner and breeder concerns […]

03020: Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs

Chronic kidney disease (CKD) is commonly encountered in small animal practice and affects up to 20% of all dogs. It is widely accepted that most dogs with stage II or greater CKD will progress to end-stage renal failure. Early detection of CKD and potential therapeutic targets in the early stages of the disease remains extremely […]

01766: Identification and Validation of the Genes That Define Abnormal Development of the Kidney in Dogs

Abnormal development of the kidneys, known as Renal Dysplasia, occurs in many breeds of dogs as well as humans. An increased prevalence in certain breeds such as Boxers, Miniature Schnauzers, Bedlington Terriers, Lhasa Apsos, Shetland Sheepdogs, and Soft Coated Wheaten Terriers suggests a genetic influence. Identification of the genetic cause in dogs is essential as […]

00872-E: Producing an Instructional Video Demonstrating the Correct Methods of Canine Bladder Expression

02807-MOU: Characterization of Renal Disease in Greyhound Dogs

Kidney disease is common in dogs, and some dog breeds seem to be more predisposed to development of kidney disease than other breeds. Greyhounds appear to be predisposed to proteinuric renal diseases; however, a complete characterization of the most common types of kidney diseases in this breed has not been performed to date, and potential […]

02437-MOU: Characterization of Renal Disease in American Boxer Dogs

Chronic kidney disease (CKD) is often a progressive and fatal disease in dogs. Boxer dogs appear to have a predisposition for development of CKD, suggesting that kidney disease in this breed might be heritable. Studies in Europe report an increased frequency of Boxers with kidney and urinary tract maldevelopments leading to CKD, termed “juvenile nephropathy”. […]

0001946: Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests

Cystinuria is an inherited disease that affects the transport of amino acids, the protein building blocks, across the membranes of cells. In the disease cystinuria, the effects of improper transport particularly affect the kidney and urinary tract where the amino acid cystine precipitates to form bladder and kidney stones that can cause life-threatening complications. Cystinuria […]

03106: Clinical Validation of Urinary miR-126 as a Marker of Immune Complex- Mediated Glomerulonephritis in Dogs

Chronic kidney disease is a significant cause of illness and death in dogs and is often caused by glomerular diseases. A specific category of glomerular disease called immune-complex glomerulonephritis (ICGN) accounts for approximately 50% of dogs that have a kidney biopsy due to suspicion of glomerular disease. The treatment for ICGN compared with other glomerular […]

00386: Elucidation of the Genetic Defect in Familial Renal Disease in the Norwegian Elkhound

Familial Renal Disease is a hereditary disease in the Norwegian Elkhound that causes kidney failure at a young age. Unfortunately, the disease is progressive and incurable. Diagnosing the disease is difficult because it requires a kidney biopsy and because of a variable expression and a late onset of signs of illness. This is the reason […]

0001858: Identifying the Genetic Causes of Renal Dysplasia in Shih Tzu, Lhasa Apso and Soft Coated Wheaten Terriers

This research has narrowed the search for the gene for renal dysplasia to two genes in a region of the genome that has caused kidney disease similar to juvenile renal disease (JRD) in humans. JRD, a genetic disease in which the kidneys fail to develop normally, is thought to occur in 31 breeds. It is […]