Knowledge Hub
Access valuable information to help pet owners and veterinarians improve canine health and quality of life.
Kidney & Bladder Health Research
The AKC Canine Health Foundation (CHF) supports research into the causes and treatments of kidney and bladder diseases in dogs.
Read More02066: Identification of Novel Biomarkers and Therapeutic Targets for Chronic Kidney Disease in Dogs
Chronic kidney disease is a significant cause of illness and death in dogs. Early treatment can prolong the lives of dogs with chronic kidney disease, but timely detection can be difficult. The outcome for each patient using current, early non-invasive testing is unpredictable. Therefore, improvements in tests to detect kidney damage at an earlier stage […]
Read More01658: Early Detection of Chronic Kidney Disease to Prevent Kidney Damage
Chronic Kidney Disease (CKD) is a significant source of illness and death in dogs, affecting up to 15% of elderly individuals. Dysfunction of the kidney filtration system is most often the cause of CKD. Early treatment generally prolongs the lives of dogs with CKD, but timely detection can be difficult and the outcome for each […]
Read More02807-MOU-T: Characterization of Renal Disease in Greyhound Dogs
Kidney disease is common in dogs, and some dog breeds seem to be more predisposed to development of kidney disease than other breeds. Greyhounds appear to be predisposed to proteinuric renal diseases; however, a complete characterization of the most common types of kidney diseases in this breed has not been performed to date, and potential […]
Read More02110-A: Investigating the Effects of an Infusion of Fenoldopam on Kidney Function to Improve Outcomes of Acute Kidney Injury Patients
Acute kidney injury (AKI) is a devastating disease in canine patients. AKI represents a spectrum of disease characterized by a rapid loss of kidney function, resulting in impaired kidney filtration of metabolic waste products. Regardless of the inciting injury, the resulting kidney dysfunction causes increased serum kidney values and often decreased urine production. The resulting […]
Read More02807-MOU: Characterization of Renal Disease in Greyhound Dogs
Kidney disease is common in dogs, and some dog breeds seem to be more predisposed to development of kidney disease than other breeds. Greyhounds appear to be predisposed to proteinuric renal diseases; however, a complete characterization of the most common types of kidney diseases in this breed has not been performed to date, and potential […]
Read More03026: Evaluation of the Efficacy of Antioxidant Treatment on Active Kidney Damage and Oxidative Stress
Chronic kidney disease (CKD) is associated with decreased kidney function and accumulation of toxins in the body. The irreversible disease is common in dogs and progressive in nature. Due to its rapid progression, the disease ultimately becomes fatal. Progression is associated with reduced quality of life and longevity. As CKD is incurable, slowing down its […]
Read More02437-MOU: Characterization of Renal Disease in American Boxer Dogs
Chronic kidney disease (CKD) is often a progressive and fatal disease in dogs. Boxer dogs appear to have a predisposition for development of CKD, suggesting that kidney disease in this breed might be heritable. Studies in Europe report an increased frequency of Boxers with kidney and urinary tract maldevelopments leading to CKD, termed “juvenile nephropathy”. […]
Read More03283: Investigating the Immune and Cytoreductive Activities of Gilvetmab Alone and in Combination with Indoleamine 2,3-Dioxygenase Inhibition in Canine Urothelial Carcinoma
Bladder cancer in dogs causes longstanding pain and discomfort with eventual death from the inability to urinate. In some dogs diagnosed with bladder cancer, supportive treatment with urinary catheters to alleviate urinary obstruction and intravenous fluids to support general kidney health can improve quality of life for a short period of time. However, few treatment […]
Read More03020-T: Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs
CKD is commonly encountered in small animal practice, and affects up to 20% of all dogs. It is widely accepted that most dogs with stage II or greater CKD will progress to end-stage renal failure. Early detection of CKD and potential therapeutic targets in early stages of disease remains extremely challenging. Management of CKD in […]
Read More03463: Efficacy of Alkaline Therapy as a Treatment of Metabolic Acidosis in Dogs with Chronic Kidney Disease
Despite medical advances in veterinary nephrology, dogs with chronic kidney disease (CKD) eventually succumb to their disease. Additional medical approaches to address disease progression are urgently needed to treat this common condition in dogs. Emerging evidence in veterinary and human medicine highlights the importance of metabolic acidosis, which has been linked to major adverse clinical […]
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