Knowledge Hub
Access valuable information to help pet owners and veterinarians improve canine health and quality of life.
Hemangiosarcoma Research
The AKC Canine Health Foundation (CHF) funds research to better understand hemangiosarcoma, an aggressive cancer, with a focus on developing advanced diagnostics and more effective treatments.
Read MoreCanine Hemangiosarcoma – The Road from Despair to Hope
Michelle G. Ritt, DVM, DACVIM; Tessa Breen, BSc (Hons), Dip GD, CMM In following article, we describe the current state of knowledge for canine hemangiosarcoma, including what it is, why it may happen, and how it can be managed. In addition, we present recent findings from our programs that promise to help us improve our […]
Read MoreResearching New Treatments for Canine Hemangiosarcoma
Hemangiosarcoma is a deadly cancer of the cells that line blood vessels. It most commonly affects the spleen, heart, and skin of dogs. While skin tumors can often be cured by surgical removal, the prognosis for splenic hemangiosarcoma is poor due to microscopic spread of cancer cells throughout the body by the time it is […]
Read MoreResearch Updates from the 2019 AKC Canine Health Foundation National Parent Club Canine Health Conference
The AKC Canine Health Foundation (CHF), a non-profit organization dedicated to advancing the health of all dogs and their owners, hosted the 2019 National Parent Club Canine Health Conference in St. Louis, MO on August 9 – 11, 2019. The biennial event, sponsored by Purina, brought together researchers, American Kennel Club (AKC) Parent Club members, […]
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Sniffing Out a Silent Killer
For thousands of years, dogs’ extraordinary noses have helped humans track game, detect predators, and navigate the world.
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From Diagnosis to Discovery: Charting a New Course for Hemangiosarcoma Treatment
If you’ve ever had a dog with hemangiosarcoma, you know how devastating it can be. Often called the “silent killer,” hemangiosarcoma is a cancer of the cells that line blood vessels. It can appear anywhere in the body, but most commonly develops in the spleen and heart. The disease gets its nickname because it rarely […]
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American German Shepherd Dog Charitable Foundation and AKC Canine Health Foundation Join Efforts for Canine Hemangiosarcoma Research
MEDIA CONTACT: Bradford Brad, Director of Development and Communications, AKC Canine Health Foundation, Phone: 919-334-4023, E-mail: bradford.brady@akcchf.org MEDIA CONTACT: Debra Ann Hokkanen, President, American German Shepherd Dog Charitable Foundation, Phone: 508-852-4473 Ellie Carson, Treasurer, American German Shepherd Dog Charitable Foundation News Release For Immediate Release RALEIGH, NC (December 21, 2018) – The AKC Canine Health Foundation (CHF), working alongside the American German Shepherd […]
Read More Flat-Coated Retriever Foundation and Golden Retriever Foundation Add Matching Funds for Canine Hemangiosarcoma Research
MEDIA CONTACT:Bradford BradyDirector of Development and CommunicationsAKC Canine Health FoundationPhone: 919-334-4023E-mail: bradford.brady@akcchf.org MEDIA CONTACT:Cheryl KistnerPresidentFlat-Coated Retriever FoundationPhone: 847-381-1808E-mail: FCRF@yahoogroups.com MEDIA CONTACT:John CotterPresidentGolden Retriever FoundationE-mail: president@goldenretrieverfoundation.org News Release For Immediate Release RALEIGH, NC (September 19, 2018) – The AKC Canine Health Foundation (CHF) has extended their matched funding opportunity for the 2018 Hemangiosarcoma Research Initiative. To […]
Read More01429: Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma
Grant Status: Closed Grant Amount: $100,000 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2011 – June 30, 2013 Sponsor(s): American Bullmastiff Association, Boston Terrier Club of America, Briard Club of America Health & Education Trust, Flat-Coated Retriever Foundation, Golden Retriever Foundation, Plum Creek Kennel Club of Colorado, Rhodesian Ridgeback Club of the […]
Read More02946: Towards Curative Outcomes in Canine Hemangiosarcoma
Canine hemangiosarcoma is the most aggressive cancer seen in all dogs, but disproportionately affects older, large breed dogs. Despite aggressive treatment with surgery and chemotherapy, more than 50% of dogs die due to metastatic spread of their cancer within 6 months and no significant advancements in the treatment of hemangiosarcoma have occurred in over 30 […]
Read More02864-A: Luteinizing Hormone Receptor Activation in Canine Hemangiosarcoma Cells
Hemangiosarcoma is an aggressive, silent cancer that sometimes snares its victims without any sign of illness. In the U.S., hemangiosarcoma is believed to be responsible for the deaths of tens of thousands of dogs each year. German Shepherd Dogs, Golden Retrievers, and Labrador Retrievers are most commonly affected but this cancer affects all dogs. While […]
Read More03481: Canine splenic hemangiosarcoma transcriptomics
Splenic hemangiosarcoma is a devastating cancer of older, large-breed dogs with short survival times even with treatment. Similarly, human angiosarcoma is a rare but devastating cancer with short survival times. Similarities exist between hemangiosarcoma and angiosarcoma, but we have limited information on what drives metastasis in these tumors. The objective of this project is to […]
Read More02234-MOU: A Novel Approach for Prevention of Canine Hemangiosarcoma
Hemangiosarcoma, an aggressive form of cancer in dogs, is the cause of death for one out of every five Golden Retrievers in the United States. Portuguese Water Dogs and Boxers also have an especially high risk for this disease which is devastating for all dogs. Hemangiosarcoma is incurable partly because the cancer is detected at […]
Read More01175-A: Pilot Investigation of the Causes of Hemangiosarcoma in Clumber Spaniels
Grant Status: Closed Grant Amount: $11,988 Nicholas S. Duesbery, PhD; Van Andel Research Institute June 1, 2008 – May 31, 2009 Sponsor(s): Breed(s): Clumber Spaniel Research Program Area: Oncology – Hemangiosarcoma Donate to Support this Research Program Area Project Summary Hemangiosarcomas (HSA) are soft-tissue tumors that arise from cells that line the inside of blood […]
Read More American German Shepherd Dog Charitable Foundation Continues Matching Funds to Support Hemangiosarcoma Research
MEDIA CONTACT:Sharon M. Albright, DVM, CCRTManager of Communications & Veterinary OutreachAKC Canine Health FoundationPhone: 919-334-4019E-mail: sharon.albright@akcchf.org News Release For Immediate Release RALEIGH, NC (October 2, 2020) – The AKC Canine Health Foundation (CHF), a nonprofit organization dedicated to advancing the health of all dogs, announces that donations in support of its Hemangiosarcoma Research Initiative will […]
Read More01355-A: Expression of Vascular Endothelial markers in Canine Hemangiosarcoma and their use in Diagnostic Cytology Using Immunocytochemistry
Canine hemangiosarcoma is an aggressive malignant tumor of the blood vessels which occurs most commonly in the spleen, heart and skin. Patients diagnosed with hemangiosarcoma in a location other than the skin have a very poor prognosis and these patients generally die from their disease in a short amount of time despite aggressive treatments including […]
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Finally, a New Frontier in the Fight Against Hemangiosarcoma
You bring your older, large-breed dog in for their annual physical. They’ve slowed down a bit on walks, but overall, they seem healthy and all the lab work comes back normal—nothing unusual. A week later, they collapse. At the emergency veterinary hospital, the diagnosis is grim: acute internal bleeding caused by hemangiosarcoma, an aggressive cancer […]
Read More AKC Canine Health Foundation Announces $432,000 Grant to Fight Cancer in Dogs
News Release For Immediate Release The AKC Canine Health Foundation (CHF), a nonprofit organization dedicated to preventing, treating, and curing diseases in all dogs, is pleased to announce the funding of an exciting grant which aims to better understand and prevent hemangiosarcoma, an aggressive form of cancer in dogs. Three groups whose dogs […]
Read More01759: Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma
Grant Status: Closed Grant Amount: $233,914 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2013 – December 31, 2015 Sponsor(s): American Belgian Tervuren Club, Inc., American Bouvier des Flandres Club – Bouvier Health Foundation, American German Shepherd Dog Charitable Foundation, Inc., American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics […]
Read More02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
Co-investigators: David R. Brown, PhD; University of Minnesota, Michael O. Childress, DVM, MS; Purdue University, Jennifer Mahoney, DVM and Pascale Salah; University of Pennsylvania Canine hemangiosarcoma is a largely incurable cancer in dogs, and treatment approaches to improve outcomes have remained relatively stagnant over the past few decades. Treatment remains a challenge partly because the […]
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