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Access valuable information to help pet owners and veterinarians improve canine health and quality of life.
Hemangiosarcoma Research
The AKC Canine Health Foundation (CHF) funds research to better understand hemangiosarcoma, an aggressive cancer, with a focus on developing advanced diagnostics and more effective treatments.
Read More02759: Reprogramming the Tumor Immune Niche in Canine Hemangiosarcoma
Hemangiosarcoma (HSA) is a common, devastating disease of dogs. The malignant tumor is seen frequently in older Golden Retrievers, German Shepherd Dogs, Portuguese Water Dogs, Labrador Retrievers, and Schnauzers, but it can occur in any dog of any breed at any age. Survival times of dogs with the tumor are short, even with surgical removal […]
Read MoreResearching New Treatments for Canine Hemangiosarcoma
Hemangiosarcoma is a deadly cancer of the cells that line blood vessels. It most commonly affects the spleen, heart, and skin of dogs. While skin tumors can often be cured by surgical removal, the prognosis for splenic hemangiosarcoma is poor due to microscopic spread of cancer cells throughout the body by the time it is […]
Read More02946: Towards Curative Outcomes in Canine Hemangiosarcoma
Canine hemangiosarcoma is the most aggressive cancer seen in all dogs, but disproportionately affects older, large breed dogs. Despite aggressive treatment with surgery and chemotherapy, more than 50% of dogs die due to metastatic spread of their cancer within 6 months and no significant advancements in the treatment of hemangiosarcoma have occurred in over 30 […]
Read More01429: Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma
Grant Status: Closed Grant Amount: $100,000 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2011 – June 30, 2013 Sponsor(s): American Bullmastiff Association, Boston Terrier Club of America, Briard Club of America Health & Education Trust, Flat-Coated Retriever Foundation, Golden Retriever Foundation, Plum Creek Kennel Club of Colorado, Rhodesian Ridgeback Club of the […]
Read More02864-A: Luteinizing Hormone Receptor Activation in Canine Hemangiosarcoma Cells
Hemangiosarcoma is an aggressive, silent cancer that sometimes snares its victims without any sign of illness. In the U.S., hemangiosarcoma is believed to be responsible for the deaths of tens of thousands of dogs each year. German Shepherd Dogs, Golden Retrievers, and Labrador Retrievers are most commonly affected but this cancer affects all dogs. While […]
Read More02234-MOU: A Novel Approach for Prevention of Canine Hemangiosarcoma
Hemangiosarcoma, an aggressive form of cancer in dogs, is the cause of death for one out of every five Golden Retrievers in the United States. Portuguese Water Dogs and Boxers also have an especially high risk for this disease which is devastating for all dogs. Hemangiosarcoma is incurable partly because the cancer is detected at […]
Read More01175-A: Pilot Investigation of the Causes of Hemangiosarcoma in Clumber Spaniels
Grant Status: Closed Grant Amount: $11,988 Nicholas S. Duesbery, PhD; Van Andel Research Institute June 1, 2008 – May 31, 2009 Sponsor(s): Breed(s): Clumber Spaniel Research Program Area: Oncology – Hemangiosarcoma Donate to Support this Research Program Area Project Summary Hemangiosarcomas (HSA) are soft-tissue tumors that arise from cells that line the inside of blood […]
Read More01355-A: Expression of Vascular Endothelial markers in Canine Hemangiosarcoma and their use in Diagnostic Cytology Using Immunocytochemistry
Canine hemangiosarcoma is an aggressive malignant tumor of the blood vessels which occurs most commonly in the spleen, heart and skin. Patients diagnosed with hemangiosarcoma in a location other than the skin have a very poor prognosis and these patients generally die from their disease in a short amount of time despite aggressive treatments including […]
Read More01759: Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma
Grant Status: Closed Grant Amount: $233,914 Jaime F Modiano, VMD, PhD; University of Minnesota January 1, 2013 – December 31, 2015 Sponsor(s): American Belgian Tervuren Club, Inc., American Bouvier des Flandres Club – Bouvier Health Foundation, American German Shepherd Dog Charitable Foundation, Inc., American Pointer Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics […]
Read More02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
Co-investigators: David R. Brown, PhD; University of Minnesota, Michael O. Childress, DVM, MS; Purdue University, Jennifer Mahoney, DVM and Pascale Salah; University of Pennsylvania Canine hemangiosarcoma is a largely incurable cancer in dogs, and treatment approaches to improve outcomes have remained relatively stagnant over the past few decades. Treatment remains a challenge partly because the […]
Read More02806-MOU: Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up
The Shine On project is designed to utilize complementary technologies to reduce the impact of hemangiosarcoma in companion dogs. This novel, potentially disruptive approach is the first of its kind where artificial intelligence applied to the results of a blood test will be used to assign dogs to a risk category for the development of […]
Read More02217: A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma
Hemangiosarcoma is an extremely aggressive cancer that is rapidly fatal in dogs. While the lifetime risk is alarmingly high for some breeds such as Golden Retrievers and German Shepherd Dogs, the disease does not discriminate, and it can strike any dog at any time. Despite considerable efforts by veterinarians and scientists to find effective treatments, […]
Read More01139: Immune Targeting of Canine Hemangiosarcoma Using a Canine Derived Single Chain Antibody Approach
Canine hemangiosarcoma is a common and highly aggressive tumor of blood vessels that is oftentimes fatal. At diagnosis most dogs have evidence of metastatic disease and despite chemotherapy, survival times rarely exceed 6 months. Novel approaches to the treatment of this disease are needed. Our work supported by CHF and its associated breed clubs aimed […]
Read More01925-A: Discovery of Novel Micro-Ribonucleic Acids for Diagnosis and Prognosis of Canine Hemangiosarcoma
Grant Status: Closed Grant Amount: $12,960 Bruce F Smith, VMD, PhD; Auburn University April 1, 2013 – May 31, 2014 Sponsor(s): Breed(s): Golden Retriever Research Program Area: Oncology – Hemangiosarcoma Donate to Support this Research Program Area Project Summary To date, all samples have been collected (5 normal spleens, 5 splenic nodular hyperplasias, 5 splenic […]
Read More00593B: Mapping Genes Associated with Canine Hemangiosarcoma
Hemangiosarcoma (HSA), a malignant tumor of vascular endothelial cells, is a significant health concern in dogs, with an incidence of ~2% of all tumors. A national heath survey of golden retriever reported that neoplasia accounted for >60% of all reported deaths and HAS was the most common malignant tumor affecting >15% of golden retrievers. A […]
Read More00593A: Mapping Genes Associated with Canine Hemangiosarcoma
Hemangiosarcoma (HSA), a malignant tumor of vascular endothelial cells, is a significant health concern in dogs, with an incidence of ~2% of all tumors. A national heath survey of golden retriever reported that neoplasia accounted for >60% of all reported deaths and HAS was the most common malignant tumor affecting >15% of golden retrievers. A […]
Read More03286: Single Nucleus RNA Sequencing of Canine Hemangiosarcoma – A Comparative Study of Splenic, Extra-Splenic, and Metastatic Tumor Profiling for Targeted Therapeutic Development
Hemangiosarcoma is a cancer originating from the lining of blood vessels, predominantly affecting larger dogs. These dogs often present as an emergency because they have a bleeding mass in their abdomen. Unfortunately, this aggressive cancer spreads rapidly, and most affected dogs survive only 23 months after surgical removal of their bleeding tumor, with chemotherapy extending […]
Read More03187: Investigating Volatile Organic Compounds as Potential Markers of Canine Hemangiosarcoma by Trained Bio-detection Dogs
Canine hemangiosarcoma (HSA) is an insidious cancer with a high mortality rate. The goal of the proposed research is to investigate whether HSA has a distinctive odor profile that is detectable by trained dogs. Bio-detection dogs are part of a new and changing face of medical diagnoses and testing. It has already been established that […]
Read More01168-A: Identifying Mutations in Genes Associated with Canine Hemangiosarcoma: Denser Fine Mapping of the Associated Locus in Chromosome 5
Hemangiosarcoma (HSA), a malignant tumor of blood vessels, is a significant health concern in dogs, with a reported incidence of up to 2% of all tumors. HSA can affect all dogs, but a particularly high disease incidence has been reported in certain breeds, such as golden retriever (15%), German shepherd (10%), and Labrador retriever. The […]
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