Epilepsy is the most common chronic neurological disorder in dogs. Over half of affected dogs are diagnosed with idiopathic epilepsy, a clinical syndrome characterized by repeated seizures for which there is no underlying cause other than a presumed genetic predisposition. An inherited basis for epilepsy has been established in over 25 dog breeds, including the Petit Basset Griffon Vendéen (PBGV). Epilepsy has been estimated to affect 8.9% of the PBGV population. However, this number arose from a report that did not classify epilepsy according to cause, and consequently, the relative significance of the inherited form of epilepsy remains uncertain. The proposed study aims to evaluate the prevalence rate, clinical characteristics and heritable nature of epilepsy in North American PBGV dog, and to collect DNA samples from PBGV dogs with idiopathic epilepsy to support future studies into the genetics of the disorder. Information will be obtained through surveys distributed via email and social media to past and current PBGV owners. An initial survey will be widely distributed to PBGV owners inquiring whether their dog has experienced seizures. A subsequent, detailed survey and request for medical records will be sent to individuals who respond affirmatively to the initial survey. Existing PBGV databases will be utilized to guide survey distribution and facilitate pedigree analysis. Information gained from this study will assist veterinarians in the management of idiopathic epilepsy in PBGV dogs, and lay the groundwork for future genetic studies aimed at identifying a potential blood test that might be used to screen for idiopathic epilepsy in the PBGV breed.





