One of the most frustrating and common canine dermatological conditions is atopic dermatitis, an immune mediated disorder. Unfortunately, there are few effective therapies and many dogs require prolonged administration of steroids and other immunosuppressive drugs. In addition, current therapies often have a host of side effects and compliance to therapy can be challenging for most owners. Immune suppression is only partially effective, prompting newer approaches in selective immune modulation. Immune modulation holds the promise of effective and safe treatment without the side effects or complications of traditional therapy. A new vaccine has been developed that proposes to reduce the severity of canine atopic dermatitis. This vaccine re-adjusts the immune system without causing immune suppression and proposes to be both cost effective and safe. The vaccine has already entered trials in veterinary medicine with encouraging results. If successful, this vaccine would be a cost effective and safe approach to treating this common disease.