00888-A: Generation of Canine Single Chain Fragment Variable Antibody Libraries for the Identification and Targeting of Tumor-Associated Antigens in the Dog
Cancer is the leading cause of disease related death in our current canine pet population. The mainstay of cancer therapy is the systemic administration of chemotherapeutic agents that inhibit cell division and induce cell death. These agents however are not tumor-specific and frequently cause adverse side effects which limit the dose that can be given […]
0001835: Identifying the Causes of Canine Epilepsy
Grant Status: Closed Grant Amount: $25,000 George J. Brewer, MD; University of Michigan July 29, 1999 – July 28, 2000 Sponsor(s): Breed(s): -All Dogs Research Program Area: Epilepsy Initiative Donate to Support this Research Program Area Project Summary In an effort to identify the genetic cause of epilepsy in dogs, researchers sought to carry out […]
01130: Measurement of Minimal Residual Disease Using Real Time PCR in Canine Lymphoma
Grant Status: Closed Grant Amount: $83,259 Susan E. Lana, DVM; Colorado State University January 1, 2009 – June 30, 2011 Sponsor(s): American Bloodhound Club, American Bullmastiff Association, American Spaniel Club Foundation, Bernese Mountain Dog Club of America, Briard Club of America Health & Education Trust, Collie Health Foundation, English Springer Spaniel Field Trial Association Foundation, […]
01317: Mutation Detection and Functional Analysis of Multiple Loci for Osteosarcoma
Background: Osteosarcoma (OSA) is a considerable canine health concern, affecting 8,000-10,000 dogs in the United States annually. In the completed CHF study “Mapping Genes Associated with OSA in Large Breed Dogs”, the researchers identified six genomic regions associated with osteosarcoma (OSA) in Rottweilers and Greyhounds. In study 758, they conducted fine-mapping of these candidate regions […]
01186-A: Evaluation of the Soft Tissue Compartments of the Canine Manus
Grant Status: Closed Grant Amount: $11,815 Jeryl C. Jones, DVM, PhD; Virginia-Maryland Regional College of Veterinary Medicine August 1, 2008 – March 31, 2010 Sponsor(s): Akita Club of America, Inc., Bernese Mountain Dog Club of America, Newfoundland Club of America Charitable Trust, Samoyed Club of America Education & Research Foundation Breed(s): -All Dogs Research Program […]
01822: Beyond the Genome: The Intersection of Genes and the Environment in Canine Cancer
Not all genes are active at all times. DNA methylation (the addition of methyl groups to DNA) is one of several mechanisms that cells use to control gene expression. Abnormal patterns of DNA methylation have been observed in human cancer. However, methylation remains an unexplored dimension of canine disease. This seed grant to Dr. Wayne […]
00336B: Mapping of the Gene for Malignant Histiocytosis in the Bernese Mountain Dog
We are interested in finding the genes that predispose the Bernese Mountain Dog (BMD) to malignant histiocytosis (MH) for three reasons. First, we are interested in improving the health of this increasingly popular breed, which is severely affected by this deadly disease. Finding the underlying disease gene will lead to the development of genetic tests […]
01160-A: Development of Contract-Enhanced Magnetic Resonance Angiography for the Diagnosis of Congenital Vascular Liver Disease in Dogs
The proposed research of utilizing contrast-enhanced portal magnetic resonance angiography (CE-MRA) in dogs to diagnose congenital liver vascular diseases was applied to 17 dogs as planned. In all of them, the technique was easily and successfully performed, and yielded good to excellent quality images in less than 4 minutes total imaging time, which is much […]
00571-A: Identification of Canine Microsatellites Associated with Genes Known to Cause Progressive Retinal Atrophy in Dogs and Retinitis Pigmentosa in Humans
Progress retinal atrophy (PRA) is an encompassing name for a group of canine inherited retinal degenerations that affect many different breeds of dog and is the phenotypic equivalent of human retinitis pigmentosa (RP). There is no treatment to cure P/RA and no treatment to stop its progression; dogs affected with PRA invariably go blind. Mutations […]
00600: Linkage Analysis of Craniomandibular Osteopathy (CMO) in Terrier Breeds
Craniomandibular osteopathy (CMO) is a painful bone disease that affects the quality of life of both the affected animals and their owners. It is most prevalent in the Cairn Terrier, West Highland White Terrier, and Scottish Terrier breeds. Although it is possible to identify carriers of the disease gene by test breeding, this method has […]