01577: Fine Mapping of Loci for Transitional Cell Carcinoma in the Scottish Terrier, West Highland White Terrier, and Shetland Sheepdog
Cancer is a major cause of death in older dogs and treatment is often ineffective. Genetic (heritable) factors are important in development of Transitional cell carcinoma (TCC) of the bladder. The Scottish and West Highland White terriers and the Shetland sheepdog are at high risk for TCC, and a subset of dogs of each breed […]
01731: A Novel Approach to Understanding How Meningoencephalomyelitis Develops In Dogs
Grant Status: Closed Grant Amount: $31,104 Nick D Jeffery, BVSc, PhD; Iowa State University January 1, 2013 – December 31, 2014 Sponsor(s): Chihuahua Club of America, Miniature Pinscher Club of America, Inc., Pug Dog Club of America, Inc., The Yorkshire Terrier Club of America, Inc. Breed(s): Maltese, Chihuahua, West Highland White Terrier, Miniature Pinscher, Pug, […]
02452-A: Targeting the T helper Inflammatory Pathway in Meningoencephalomyelitis of Unknown Origin (MUO)
Meningoencephalomyelitis of unknown origin (MUO) is a common neurological disorder of dogs that results in inflammation of the brain and/or spinal cord causing depression, seizures, blindness, difficulty walking, and death. All dogs can be affected but young to middle aged small and toy breed dogs (such as the Chihuahua, Maltese, Pug, and Yorkshire Terrier) are […]
03283: Investigating the Immune and Cytoreductive Activities of Gilvetmab Alone and in Combination with Indoleamine 2,3-Dioxygenase Inhibition in Canine Urothelial Carcinoma
Bladder cancer in dogs causes longstanding pain and discomfort with eventual death from the inability to urinate. In some dogs diagnosed with bladder cancer, supportive treatment with urinary catheters to alleviate urinary obstruction and intravenous fluids to support general kidney health can improve quality of life for a short period of time. However, few treatment […]
02111-A: Evaluating the Contribution of Fungal Infection to the Pathogenesis of Atopic Dermatitis: Putting Evidence under the Use of Antifungal Medication
This study utilized next-generation sequencing to describe the natural fungal microbiome (mycobiome) of canine skin and to identify changes in the mycobiome when allergic skin disease is present. Superficial skin swabs from ten dogs with healthy skin and eight dogs with allergic skin disease were collected from haired and non-haired sites, 10 sites for healthy […]
02105-A: The Genetics of Keratoconjunctivitis Sicca in West Highland White Terrier
Dry eye disease or keratoconjunctivitis sicca (KCS) is a devastating disease in dogs and humans where inadequate tear production can result in ocular pain, corneal ulceration and even blindness. The most common cause for KCS in dogs is immune-mediated, which means that the dog’s immune system attacks the tear-producing glands. However, the exact mechanism by […]
01929-A: Arginine Dependence: Identification of Cancer’s Achilles Heel
Arginine is a nonessential amino acid. This means that some normal cells in the body can make their own arginine and, once they make it, put it into the circulation for others cells of the body to use for such purposes as making proteins. Interestingly, it has been shown that many tumor cells cannot make […]
02780: Bladder Carcinogen Exposures in Pet Dogs
Bladder cancer is an aggressive cancer that affects ~ 20,000 dogs per year, and often leads to euthanasia. Certain breeds have a higher incidence of bladder cancer but genetic studies even in the highest risk breeds have been inconclusive and still indicate influence from environmental exposures. The investigators propose that specific household environmental chemical exposures […]
03162: Fecal Microbiota Transplantation for Treatment of Canine Atopic Dermatitis
Atopic dermatitis is a common inflammatory and itchy skin disease, constituting a global issue that affects millions of people and dogs world-wide. The pathogenesis of this disease is known to be multifactorial and not only consisting of skin barrier dysfunction, but also with immunological dysregulation and skin microbiota changes playing a central role.In humans, establishment […]
01312: Association mapping study of Legg-Calve-Perthes Disease in the West Highland White Terrier, Yorkshire Terrier, and Cairn Terriers
Legg-Calvé-Perthes Disease (LCPD) is a developmental orthopedic disorder of the coxofemoral joint that is observed in humans and dogs. A loss of vasculature in the developing femoral head leads to necrosis and subsequent microfracture of the capital femoral epiphysis. The resultant articular incongruency reduces joint stability and can cause secondary osteoarthritis. LCPD is among the […]