03483-A: Identification of genetic risk factors underlying canine gastric cancer intestinal and diffuse tumor subtypes
This research focuses on gastric cancer, a disease with no effective treatments in dogs. Belgian Tervuren and Sheepdogs are commonly diagnosed between 8–10 years of age, shortening their lifespan by approximately six years. Our goal is to identify the genetic basis of this cancer and its two tumor subtypes, which could have a big impact […]
0002015: Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog
Idiopathic epilepsy affects nearly 30 different dog breeds and in a 1999 survey is considered one of the top canine health issues identified by the AKC Parent Clubs. Preliminary studies in the Belgian Tervuren indicates that although this is a heritable disorder governed by many genes, there exists a single gene of very large effect […]
01425: Identification of Epilepsy-Causing Mutations from the Associated Loci by Next-Generation Resequencing
Grant Status: Closed Grant Amount: $85,040.1 Hannes T Lohi, PhD; University of Helsinki and the Folkhälsan Institute of Genetics January 1, 2011 – June 30, 2012 Sponsor(s): American Belgian Tervuren Club, Inc., American Chinese Crested Club, American Spaniel Club Foundation, Australian Shepherd Health & Genetics Institute, Belgian Sheepdog Club of America, Inc., Border Terrier Club […]
00642: Investigation of the Genetic Mutations Underlying Progressive Retinal Atrophy
Grant Status: Closed Grant Amount: $104,580 Simon M. Petersen-Jones, DVM, PhD; Michigan State University July 1, 2006 – December 31, 2008 Sponsor(s): American Belgian Tervuren Club, Inc., American Chinese Crested Club, Collie Health Foundation, Italian Greyhound Club of America, Old English Sheepdog Club of America, Papillon Club of America, San Joaquin Kennel Club Breed(s): Papillon, […]
0002031: Investigation of Candidate Loci for Progressive Retinal Atrophy in the Old English Sheepdog and Papillon Breeds of Dog
Progressive retinal atrophy (PRA) is a common cause of blindness in purebred dogs. It is an inherited disease and there are several different forms resulting from defects in different genes. Most forms are due to a defect in a single gene and are inherited in an autosomal recessive manner. PRA has become a problem in […]
02936: Validating Genetic Variants Underlying Canine Idiopathic Epilepsy and Exploring Their Functional Roles in the Belgian Sheepdog and Tervuren
Canine epilepsy is a debilitating condition and, unfortunately, an all too common neurological disease with impact on a dog’s health and well-being, and a significant emotional toll on owners. Epilepsy is known to be inherited, and therefore characterizing the causal genetic alterations is important to assist in breeding decisions as well as reveal pathways that […]
The Genetics of Idiopathic Epilepsy in the Belgian Sheepdog and Belgian Tervuren
Introduction Idiopathic epilepsy is the most common medical neurologic disorder in dogs. It is defined as seizures with no identifiable cause. Despite appropriate anti-convulsant therapy, approximately 30% of affected dogs continue to have seizures. Because idiopathic epilepsy is more common in the Belgian Sheepdog and Belgian Tervuren, genetics are believed to play a role in […]