00578-A: Optimization of a DNA Test for the Deletion Mutation in MURR1 Causing Copper Toxicosis in Bedlington Terriers
Copper toxicosis in Bedlington Terriers is an autosomal recessive condition characterized by high levels of hepatic copper. The disease usually leads to liver damage and cirrhosis. Most Bedlington populations show a high incidence for this condition. Testing is currently carried out by histological examination and measurement of copper levels in liver biopsies (for affected dogs) […]
00960: Identification of Genes That Cause Liver Copper Toxicosis
Grant Status: Closed Grant Amount: $70,283.58 Andrew Mason, PhD; University of Alberta September 1, 2008 – September 30, 2013 Sponsor(s): Berner Lovers, Bernese Mountain Dog Club of America, Flat-Coated Retriever Foundation, Golden Retriever Foundation Breed(s): Bedlington Terrier Research Program Area: Hepatic Disease Donate to Support this Research Program Area Project Summary Bedlington terriers, and some […]
0001444: Linkage Analysis Between Canine ATP7B Gene Markers and Heritable Copper Toxicosis in Bedlington Terriers
Copper toxicosis is an autosomal recessive disease (affected dogs must receive a gene from each parent) in which there is an accumulation of copper in the dogs body, resulting in severe liver disease. The Bedlington Terrier is one of the breeds most affected by this disease. Humans suffer from a similar heritable disease called Wilsons […]
00981-A: Collecting DNA for Identifying Modifiers of COMMD1 in Bedlington Copper Toxicosis
Bedlington Terriers, and other breeds such as the Skye Terrier, the West Highland White Terrier and the Doberman Pinscher, develop copper storage that can lead to early death from liver disease (copper toxicosis (CT). Recently, the gene COMMD1 was reported to be the cause of the liver disease in Bedlingtons, as a deletion of the […]
02515-A: Investigating the Role of Interleukin-17-producing Cells in the Pathophysiology of Canine Immune Mediated Hemolytic Anemia
Canine primary immune-mediated hemolytic anemia (IMHA) is an acute and severe disease of dogs, with a mortality rate ranging up to 70%. IMHA is caused when the immune system produces abnormal antibodies that attack and destroy the dog?s own red blood cells. It is not known how or why these abnormal antibodies form in the […]
01678-A: Apoptosis — not just for Nucleated Cells: the Contribution of Programmed Cell Death to Red Cell Destruction in Immune-Mediated Hemolytic Anemia
Red blood cells (RBCs) are biconcave cells that circulate in the blood stream and provide oxygen to all tissues of the body. The number and lifespan of circulating RBCs are tightly regulated. “Old” RBCs undergo alterations that result in their recognition and removal from circulation by cells in the spleen (macrophages), whereas replacement RBCs are […]
02363-A: Platelet Function in Dogs with Chronic Liver Disease
Chronic liver disease is common among adult dogs with numerous breeds being predisposed. Liver biopsy is usually required to identify the underlying cause of liver disease in these patients, and is often recommended to monitor response to treatment. Because dogs with liver disease have abnormal clotting activity, bleeding is a substantial risk of biopsy. Routine […]