00311-A: A Continued Molecular Genetic Study of Fanconi Syndrome in Basenjis
Canine Fanconi Syndrome is an inherited adult-onset kidney disease, common among Basenjis. It can be fatal if untreated. We want to identify the mutation responsible for Fanconi Syndrome in Basenjis. If successful, we will be able to devise a DNA marker assay to identify affected dogs so they can receive early treatment and to identify […]
0002462: Molecular Genetic Study of Fanconi Syndrome in Basenjis
The Basenji Club of America considers Fanconi Syndrome the problem of highest priority in the 2001 Parent Club Survey. Our long-term goals are to identify the mutation responsible for Fanconi Syndrome in Basenjis and to use this information to design a DNA-based test for carriers of this disease. This test would enable Basenji breeders to […]
01609: Use of Probiotic to Reduce the Symptoms of Inflammatory Bowel Disease
Idiopathic inflammatory bowel disease (IBD) is a common cause of chronic gastrointestinal disease in dogs. Accumulating evidence in human IBD and animal models suggests that imbalances in composition of the intestinal microbiota contribute to the pathogenesis of chronic intestinal inflammation. Recent studies have also shown that dogs with IBD have distinctly different duodenal microbial communities […]
0001445: Evaluation of the Canine HNF1 and HNF2 Genes as Candidates for the Locus Causing Fanconi Syndrome in Basenjis
This study ruled out two candidate genes as the gene responsible for Fanconi Syndrome (FS) in Basenjis. FS, an inherited disease, is a major health concern for the breed. With this syndrome, the tubules in the kidney, for unknown reasons, fail to do their job of reabsorbing nutrients into the dogs system. Undetected, it will […]
00801-A: Characterization of the Mutation Responsible for Fanconi Syndrome in Basenjis
We have been working to characterize the mutation responsible for Fanconi Syndrome, a serious disease of the kidney, which has been fairly common in Basenjis for many years. The disease is recessive with symptoms seldom showing up until the dogs are over 4.5 years old. It is, therefore, very hard for Basenji breeders to avoid […]
02589: Genetic Basis of Canine Spinal Abnormalities
This study will identify potential genes and risk alleles to better understand the genetic basis of canine spinal abnormalities using comparisons between affected and unaffected dogs. The identification of these genes and risk alleles will advance knowledge with an ultimate goal to develop genetic tests and/or a genetic risk model to help predict healthy spines […]
Genetic Basis of Canine Spinal Abnormalities
The Canine Genetics lab of Dr. Kari Ekenstedt, at Purdue University College of Veterinary Medicine, is heading a research project involving common dog skeletal morphology. DNA samples from purebred dogs of the following breeds are needed: Dogs of any age and health status qualify. Download a study flyer here. Contact Information: Contact Dr. Dayna Dreger […]