00812-A: Investigation of the Canine Cathepsin L Gene (CTSL) as a Candidate for Alopecia X in Keeshonden and Pomeranians
Grant Status: Closed Grant Amount: $12,600 Tosso Leeb, PhD; University of Bern December 1, 2006 – May 31, 2007 Sponsor(s): Pug Dog Club of America, Inc. Breed(s): Pomeranian, Keeshond, Samoyed, Chow Chow, Alaskan Malamute Research Program Area: Dermatology and Allergic Disease Donate to Support this Research Program Area Project Summary Alopecia X is a noninflammatory, […]
01670-A: Pinpointing the causal mutation(s) underlying a genome-wide association signal for hereditary cataract in Northern breeds
Grant Status: Closed Grant Amount: $12,960 Sally L Ricketts, PhD; Animal Health Trust July 1, 2011 – November 30, 2012 Sponsor(s): Alaskan Malamute Club of America, Inc., Norwegian Elkhound Association of America, Inc., Samoyed Club of America Education & Research Foundation, Siberian Husky Club of America Breed(s): Siberian Husky, Samoyed, Alaskan Malamute Research Program Area: […]
01074-A: The Role of Enteropathogenic Bacteria in Diarrhea in Racing Alaskan Sled Dogs
This is the first study to attempt to establish an apparent prevalence of these conditions in racing sled dogs and to attempt to define a causative etiology. The mushing community has been strongly suspicious of an infectious etiology for the occurrence of diarrhea, with recent concern focused on Clostridium spp. and leading to inappropriate use […]
02673-MOU: Searching for the Cause for Alopecia X by Whole Genome Sequencing
This study will use whole genome sequencing to identify a molecular genetic cause for a hair cycle deficiency known as Alopecia X. While the focus on the research is on the disease in Pomeranians, the results will be pertinent to other affected breeds including Alaskan Malamutes, Chow Chows, Keeshonds, Samoyeds, Schipperkes, and Siberian Husky dogs. […]
00972: Identification of Mutations Associated with Hereditary Cataracts in Northern Breeds
This study aimed to investigate the genetic cause of hereditary cataract (HC) in Northern breeds. The Investigators have collected samples from 228 dogs affected with bilateral cataract (both eyes) and 300 dogs with a clear eye examination from 15 Northern breeds, initially screening known human cataract-causing genes in 66 dogs from two of these breeds. […]
0001637: Identification of DNA Marker(s) for Cataracts in Purebred Dogs, with Emphasis on the Breeds Alaskan Malamute, Siberian Husky, and Samoyed
To better understand the mode of inheritance of canine cataracts, researchers collected extensive DNA, pedigree and clinical information from breeders and owners of Alaskan Malamutes, Siberian Huskies and Samoyeds. The data point to autosomal recessive inheritance, indicating that affected dogs must receive a gene from each parent. To try to find the genetic marker for […]
00372: Determination of Breed-Specific Reference Ranges for Assessing Thyroid Function in Several Breeds
All dogs have completed the recruitment, enrollment and screening process. All samples from all dogs have been collected. Six hundred dogs were enrolled and 77 dogs were rejected due to their failure to pass inclusion criteria. All analytical testing (health screening data and hormone analyses) has been completed. Preliminary data has been presented at the […]
02690-A: Diagnostic Utility of Thoracoscopy for Localization of Pulmonary Bullae in Dogs with Spontaneous Pneumothorax
Primary spontaneous pneumothorax is defined as the presence of air in the space around the lungs without an obvious precipitating factor. This disease presents as a life-threatening emergency causing shortness of breath, exercise intolerance, and possible collapse or sudden death. The diagnosis of these lesions that cause spontaneous pneumothorax in dogs (known as pulmonary bullae) […]
01901-A: Identifying the Gene Responsible for Dwarfism in Malamutes
The Alaskan Malamute breed suffers from a genetic skeletal condition referred to as chondrodysplasia. The condition has been extensively studied in this breed in the veterinary clinic during the 1970’s and 80’s. Affected malamutes have a disturbance in the process of bone development, which results in short stature and curvature of the front limbs. The […]