00577-A: Sebaceous Adenitis in the Akita
Sebaceous adenitis (SA) is a skin disease that is found in Akitas as well as several other dog breeds. Very typically the disease can be seen as an impaired metabolism of the skin with a chronic inflammation and leading to a destruction of the sebaceous glands. A consequence of this is a progressive loss of […]
00329-A: Genetics of Post-Squalene Cholesterol Biosynthesis in the Havanese, Akita and Samoyed: Are Defects in this Pathway Responsible for an Array of Developmental Abnormalities- A Pilot Study
This project is designed to eventually identify the causative gene(s) for post-squalene cholesterol biosynthesis. Research focused on cholesterol biosynthesis is increasingly directed towards understanding the genetics governing diseases related to this important sterol. Whereas most metabolic diseases are characterized largely by postnatal biochemical toxicities or deficiencies, disorders of cholesterol biosynthesis are notable for their severe […]
00883-A: Training and Racing Associated Hypoglobulinemia in Elite Alaskan Sled Dogs
Globulin proteins play a critical role in protecting against infection. Trained Alaskan sled dogs have low blood globulin concentrations at rest with a further decline in blood globulins during long distance exercise. The cause and prevalence of this phenomenon and the specific globulin fractions affected (immunoglobulins A, E, G, and M) are currently unknown. To […]
01585: Evaluating a Safer, Less Toxic Radiation Therapy in the Treatment of Lymphoma
Grant Status: Closed Grant Amount: $93,140 Michael A. Deveau, DVM, MS; Texas A&M Research Foundation January 1, 2012 – June 30, 2014 Sponsor(s): American Foxhound Club, American German Shepherd Dog Charitable Foundation, Inc., American Spaniel Club Foundation, Clumber Spaniel Club of America, English Setter Association of America, Inc., Keeshond Anonymous Fund, Pembroke Welsh Corgi Club […]
0001432: The Genetics of the Major Histocompatibility Complex in Canine Immune-Mediated Disease
In these studies, researchers mapped molecular markers in the Major Histocompatibility Complex (MHC), the receptors on the cell surface that present foreign proteins and trigger an immune response. This mapping was done for normal Akitas. They then applied these markers to two immune-mediated diseases in Akitas, myasthenia gravis, a muscle-related disease, and uveodermatologic disease, a […]
00577-AT: Sebaceous Adenitis in the Akita
Sebaceous adenitis (SA) is a skin disease that is found in Akitas as well as several other dog breeds. Very typically the disease can be seen as an impaired metabolism of the skin with a chronic inflammation and leading to a destruction of the sebaceous glands. A consequence of this is a progressive loss of […]
00326-A: Microphthalmia, Merle and MITF in Dogs
Dogs with microphthalmia and/or related eye disorders will be studied using the Microphthamia transcription fector gene (MITF) as a candidate gene. Because this gene causes this problem in mice it seems a reasonable candidate. mRNA from 2 microphthalmic Akitas will be examined and compared to sequence from unaffected dogs which we have already obtained. Families […]
0002272: Localization of the Gene for Sebaceous Adenitis in the Akita Dog by Homology Mapping
Whenever I discuss with lay audiences the devastating effect genetic diseases can have on purebred dogs, I describe sebaceous adenitis (SA). A disease common in breeds like the Akita and Standard Poodle, severely affected dogs are largely hairless, covered in scale and smell terribly. There is no cure. Because the disease seldom shows itself until […]
01937-B: Evaluating the Complex Genetic Basis of Bloat
Gastric dilatation and volvulus (GDV), or bloat, is a common condition in large and giant breed dogs with an unacceptably high morbidity and mortality rate. Due to the importance of GDV in many dog breeds, several previous studies have investigated potential risk factors for the development of GDV. It is known that there is no […]
0001629: The Genetics of the Major Histocompatibility Complex in Canine Immune-Mediated Diseases
In these studies, researchers mapped molecular markers in the Major Histocompatibility Complex (MHC), the receptors on the cell surface that present foreign proteins and trigger an immune response. This mapping was done for normal Akitas. They then applied these markers to two immune-mediated diseases in Akitas, myasthenia gravis, a muscle-related disease, and uveodermatologic disease, a […]