Chylothorax is a disease in which lymph leaks into the thorax causing coughing, difficulty breathing, a weakened immune system and/or severe metabolic disorders. Previous publications report that some Afghan Hounds are more likely to develop chylothorax. The reason for the greater susceptibility of some Afghan Hounds is unknown, but many authorities have suggested a mutation as a yet unidentified gene may be responsible. The investigators will compare the DNA of affected and healthy Afghan Hounds, in an effort to discover a mutation that increases susceptibility for developing chylothorax in some Afghan Hounds.

Funding for the research is provided through the collaborative efforts and generosity of Afghan Hound Club of America and William Dean III Charitable Trust. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration and scientific progress.