2022 Awarded Grants

Our new grants for 2022 are listed below.  Please see our Research Grants Portfolio for a full list of our active grants.
To support one of these grants, or any of the research program areas, please visit our website or use our donation form. If you would like to discuss research support opportunities, please email chfgrants@akcchf.org.



 Research Program


Sentinel Lymph Node Mapping for Dogs with Lung Tumors



Mapping Microstructural Myelin and Axonal Damage in Dogs with Idiopathic Epilepsy using Diffusion MRI and Tract-Based Spatial Statistics

Epilepsy Initiative


Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs

Kidney & Urological Disease


Catechol O-Methyltransferase as a Molecular Drug Target in Heartworm

Cardiology, Immunology and Infectious Disease


Early Detection of Canine Osteosarcoma

Oncology - Osteosarcoma


Tolerability and Clinical Efficacy of Acetazolamide for Treatment of Hypochloremia in Canine Congestive Heart Failure



Evaluation of the Efficacy of Antioxidant Treatment on Active Kidney Damage and Oxidative Stress

Kidney & Urological Disease


Judicious Antibiotic Use in Cases of Canine Pyelonephritis

Kidney & Urological Disease


Molecular Characterization of Canine Soft Tissue Sarcomas Using Spatially Defined Proteomics and Transcriptomics



Evaluating Magnetic Resonance Imaging for Quantifying Histotripsy Ablation in Canine Osteosarcoma

Oncology - Osteosarcoma


Evaluation of a Targeted Anti αvβ3 Integrin Near-InfraRed (NIR-) Dye for Controlled Resection of Naturally Occurring Soft Tissue Sarcomas in Dogs

Oncology - Osteosarcoma, Oncology


Evaluating Accuracy for Identification of Sentinel Lymph Nodes in Dogs with Cutaneous MCT: A Comparison



The Immune and Molecular Landscape of Canine Osteosarcoma at the Single-Cell Level

Oncology - Osteosarcoma


Suppression of Extracellular Glutamate Efflux & mGluR1 Signaling to Impede Canine Hemangiosarcoma Cell Growth

Oncology - Hemangiosarcoma


A GD3 Nano-scaled Liposomal Cancer Vaccine Clinical Trial for Canine Hemangiosarcoma

Oncology - Hemangiosarcoma


Investigating Extracellular Crosstalk Between Canine Osteosarcoma and Macrophages

Oncology - Osteosarcoma


Chimeric BiTE-redirected Anti-viral T Cells for Fratricide of Minimal Residual Disease in T-cell Malignancies

Oncology - Lymphoma


Whole-Exome and Transcriptome Sequencing of Canine Small Cell B Cell Lymphoma and Comparative Analysis to Diffuse Large B Cell Lymphoma

Oncology - Lymphoma


Characterizing the Immunomodulatory Response of Histotripsy in Canine Osteosarcoma

Oncology - Osteosarcoma


Genome-wide Identification and Characterization of Peptide Epitopes from Ehrlichia canis and Anaplasma platys with Potential to be Used as Vaccine Candidates

Tick-Borne Disease Initiative


Evaluation of Serum C-reactive Protein as a Noninvasive Biomarker of Inflammation and Disease Severity in Dogs with Gallbladder Mucocele

Hepatic Disease


Corneal Cross-linking as Treatment for Corneal Ulceration - “Using Light to Save Sight”



Characterizing Immunohistopathology and Serum Immunoglobulin G in Immune-Mediated Chronic Hepatitis Dogs

Hepatic Disease


Canine Systemic Insecticides as a Novel Intervention to Protect Dogs from Triatomine Insect Vectors of Chagas Disease

Immunology and Infectious Disease


Enhanced Detection and Characterization of Spotted Fever Group Rickettsia Species in Dogs and Ticks with Focus on a Novel Rickettsia Species Infecting Clinically Ill Dogs in the U.S.

Tick-Borne Disease Initiative , Immunology and Infectious Disease


It’s All In The Genes: The Mutational Landscape of Acute Myeloid Leukemia in Dogs

Blood Disorders, Oncology


Plasminogen-activator Inhibitor-1 (PAI-1) and Impaired Fibrinolysis in Immune-Mediated Hemolytic Anemia

Blood Disorders

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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