2022 Awarded Grants

Our new grants for 2022 are listed below.  Please see our Research Grants Portfolio for a full list of our active grants.
To support one of these grants, or any of the research program areas, please visit our website or use our donation form. If you would like to discuss research support opportunities, please email chfgrants@akcchf.org.



 Research Program


The Effect of Overweight and Obesity on Adult Stem Cell Function for Regenerative Therapies in Dogs

Musculoskeletal Conditions and Disease


Can Deep Learning (CNN) Detect Minimal Residual Disease (MRD) in Dogs Treated for Lymphoma?

Oncology - Lymphoma


The Use of Artificial Intelligence and Computed Tomography Image Features to Predict Sentinel Lymph Node Metastasis in Dogs with Oral Tumours



Identification of Gene Mutation Underlying Ocular Melanosis in Cairn Terriers



Investigation into the Prevalence and Clinical Significance of Vector-borne Pathogen Coinfections in a Population of Trypanosoma cruzi-infected Dogs from Texas

Immunology and Infectious Disease


Optimizing GBLUP and Machine Learning Genomic Breeding Values for Health and Performance Traits in Working Dogs

General Canine Health


Comparison of Sedated Respiratory-Gated Computed Tomography (CT) to Anesthetized Inspiratory:Expiratory Breath Hold CT in Dogs

Lung and Respiratory Disease


AGILE (AGility Innovations Leveraging Electronics) - An Initial Study of Technology for Quantifying Canine Agility-specific Activity

Musculoskeletal Conditions and Disease


Evaluating Reproductive Diseases in vitro with a 3D Canine Endometrial Organoid Model

Reproductive Conditions


Cooling Strategies During Exertional Hyperthermia

General Canine Health


Sentinel Lymph Node Mapping for Dogs with Lung Tumors



Prognostic Biomarkers for the Development of Drug Resistance in Dogs with Idiopathic Epilepsy

Epilepsy Initiative


Thoracoscopic-Guided Autologous Blood Injection for Treatment of Primary Spontaneous Pneumothorax

Lung and Respiratory Disease


Identification of Novel Epilepsy Genes in Dogs

Epilepsy Initiative


Artificial Intelligence and Machine Learning for Diagnosis of Dog Sperm Morphology

Reproductive Conditions


Antimicrobial Resistance in the Canine Vaginal Microbiome

Reproductive Conditions


Mapping Microstructural Myelin and Axonal Damage in Dogs with Idiopathic Epilepsy using Diffusion MRI and Tract-Based Spatial Statistics

Epilepsy Initiative


Novel Biomarker and Therapeutic Target for Chronic Kidney Disease in Dogs

Kidney & Urological Disease


Judicious Antibiotic Use in Cases of Canine Pyelonephritis

Kidney & Urological Disease


Early Detection of Canine Osteosarcoma

Oncology - Osteosarcoma


Evaluation of the Efficacy of Antioxidant Treatment on Active Kidney Damage and Oxidative Stress

Kidney & Urological Disease


Tolerability and Clinical Efficacy of Acetazolamide for Treatment of Hypochloremia in Canine Congestive Heart Failure



Catechol O-Methyltransferase as a Molecular Drug Target in Heartworm

Cardiology, Immunology and Infectious Disease


Whole-Exome and Transcriptome Sequencing of Canine Small Cell B Cell Lymphoma and Comparative Analysis to Diffuse Large B Cell Lymphoma

Oncology - Lymphoma


Investigating Extracellular Crosstalk Between Canine Osteosarcoma and Macrophages

Oncology - Osteosarcoma


Molecular Characterization of Canine Soft Tissue Sarcomas Using Spatially Defined Proteomics and Transcriptomics



Evaluation of a Targeted Anti αvβ3 Integrin Near-InfraRed (NIR-) Dye for Controlled Resection of Naturally Occurring Soft Tissue Sarcomas in Dogs

Oncology - Osteosarcoma, Oncology


The Immune and Molecular Landscape of Canine Osteosarcoma at the Single-Cell Level

Oncology - Osteosarcoma


Suppression of Extracellular Glutamate Efflux & mGluR1 Signaling to Impede Canine Hemangiosarcoma Cell Growth

Oncology - Hemangiosarcoma


Characterizing the Immunomodulatory Response of Histotripsy in Canine Osteosarcoma

Oncology - Osteosarcoma


A GD3 Nano-scaled Liposomal Cancer Vaccine Clinical Trial for Canine Hemangiosarcoma

Oncology - Hemangiosarcoma


Chimeric BiTE-redirected Anti-viral T Cells for Fratricide of Minimal Residual Disease in T-cell Malignancies

Oncology - Lymphoma


Evaluating Accuracy for Identification of Sentinel Lymph Nodes in Dogs with Cutaneous MCT: A Comparison



Corneal Cross-linking as Treatment for Corneal Ulceration - “Using Light to Save Sight”



Evaluation of Serum C-reactive Protein as a Noninvasive Biomarker of Inflammation and Disease Severity in Dogs with Gallbladder Mucocele

Hepatic Disease


Canine Systemic Insecticides as a Novel Intervention to Protect Dogs from Triatomine Insect Vectors of Chagas Disease

Immunology and Infectious Disease


Characterizing Immunohistopathology and Serum Immunoglobulin G in Immune-Mediated Chronic Hepatitis Dogs

Hepatic Disease


Genome-wide Identification and Characterization of Peptide Epitopes from Ehrlichia canis and Anaplasma platys with Potential to be Used as Vaccine Candidates

Tick-Borne Disease Initiative


Plasminogen-activator Inhibitor-1 (PAI-1) and Impaired Fibrinolysis in Immune-Mediated Hemolytic Anemia

Blood Disorders


It’s All In The Genes: The Mutational Landscape of Acute Myeloid Leukemia in Dogs

Blood Disorders, Oncology


Enhanced Detection and Characterization of Spotted Fever Group Rickettsia Species in Dogs and Ticks with Focus on a Novel Rickettsia Species Infecting Clinically Ill Dogs in the U.S.

Tick-Borne Disease Initiative , Immunology and Infectious Disease

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

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