2021 Awarded Grants

Our new grants for 2021 are listed below.  Please see our Research Grants Portfolio for a full list of our active grants.
To support one of these grants, or any of the research program areas, please visit our website or use our donation form. If you would like to discuss research support opportunities, please email chfgrants@akcchf.org.



 Research Program


Genetics of Glaucoma in the Entlebucher Mountain Dog



Babesia Species in Thrombocytopenic Dogs in the Upper Midwest, USA

Tick-Borne Disease Initiative


Genetic Basis of non-HSF4 Hereditary Cataracts in a Family of Miniature American Shepherds



Adoptive Natural Killer (NK) Cell Immunotherapy for Canine Lymphoma

Oncology - Lymphoma


Genome-wide Molecular Interrogation of Canine Hemangiosarcoma

Oncology - Hemangiosarcoma


Assessment of Frequency of Seizures and Antiseizure Drug (ASD) Efficacy by Electroencephalography (EEG) for Dogs with Epilepsy

Epilepsy Initiative


Late-onset Hereditary Cataract in the Boston Terrier: A Whole Genome Sequencing Approach



Effect of Glycemic Control on the Onset of Cataract Development in Diabetic Dogs

Ophthalmology, Endocrinology


Development of Regional Anesthesia Techniques to Treat Chronic Painful Conditions of the Stifle and Elbow in Dogs

Musculoskeletal Conditions and Disease


Identification of Genetic Risk Factors in Degenerative Myelopathy in German Shepherd Dogs



Enhanced Surgical Margin Imaging with Polarization-sensitive Optical Coherence Tomography in Canine Soft Tissue Sarcoma and Mammary Tumors



Optimizing Storage Conditions of Canine Feces for Fecal Microbiota Transplantation

Gastrointestinal Disease


Ultrasound-guided Histotripsy Ablation of Canine Brain Tumors through an Acoustically Transparent Cranial Window



Development and Validation of a New Body Condition Scoring System for use in Canine Athletes

Musculoskeletal Conditions and Disease


Validating Genetic Variants Underlying Canine Idiopathic Epilepsy and Exploring Their Functional Roles in the Belgian Sheepdog and Tervuren

Epilepsy Initiative


A Dose Finding Study of Cannabidiol in Dogs with Idiopathic Epilepsy

Epilepsy Initiative


Understanding the Genetic Basis of Addison’s Disease in Portuguese Water Dogs



Investigating Neuronal Network Connectivity in Dogs with Idiopathic Epilepsy using Functional Magnetic Resonance Imaging

Epilepsy Initiative


How do Maternal, Environmental, and Genetic Factors Contribute to Acquisition and Evolution of the Enteric Microbiome in Dogs?

Gastrointestinal Disease


Standardization of rLiNTPDase2 and Derived Chimeras as Antigens on Immunochromatographic Assay for Diagnosis of Canine Visceral Leishmaniasis

Immunology and Infectious Disease


Transcriptome Profiling of Canine Familial Dermatomyositis Skin Lesions and Treatment with a JAK Inhibitor to Identify Novel Pathways Involved in Pathogenesis

Dermatology and Allergic Disease


Canine Pituitary Adenoma Organoids (CaPitO) as an in vitro Model for Canine Cushing's Disease



Use of CRISPR-based Genome-wide Approach for Identification of Vulnerabilities in Canine Oral Melanoma



Characterizing the LINE-1 Transcriptome in Canine High-grade Peripheral T-cell Lymphoma by RNAseq to Gain Insight into Mechanisms of Drug and Immune Resistance

Oncology - Lymphoma


Exposure to Environmental Chemicals in Boxers with Lymphoma

Oncology - Lymphoma


Continued Investigation into Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes



Investigation of Mechanisms of Resistance to Immunotherapy in Dogs with Spontaneous High-grade Glioma



Characterization of Mesenchymal Stromal Cell Properties of Canine Culture-expanded Articular Chondrocytes

Musculoskeletal Conditions and Disease


Open-Label, Phase-2 Clinical Trial of Chlorambucil and Toceranib for Canine Mast Cell Tumors



Repurposing Drugs to Modulate Myeloid-derived Suppressor Cells (MDSCs) in Canine Soft Tissue Sarcomas



Luteinizing Hormone Receptor Activation in Canine Hemangiosarcoma Cells

Oncology - Hemangiosarcoma


Acute Gastrointestinal Injury in Dogs

Gastrointestinal Disease


Potential Reduction of Systemic and Pancreatic Inflammation using Fenofibrate in Diabetic Dogs



Identification of Bartonella henselae In Vivo Induced Antigens for Development of a Reliable Serodiagnostic Assay for Canine Bartonelloses

Tick-Borne Disease Initiative


Cardiovascular Complications of Acute Pancreatitis in Dogs

Gastrointestinal Disease


Investigating the Potential of Phage Therapy to Tackle Staphylococcus pseudintermedius Infections in Dogs

Dermatology and Allergic Disease

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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