03257: B cell Subset Analysis Through Spatial Transcriptomics with Application to B cell Disorders

Grant Status: Open

Grant Amount: $42,263
Emily D Rout, DVM, PhD; Colorado State University
August 1, 2024 - July 31, 2026

Sponsor(s):

Breed(s): Field Spaniel, Boykin Spaniel, Wirehaired Vizsla, Flat-Coated Retriever, Wirehaired Pointing Griffon, English Springer Spaniel, Vizsla, English Setter, Lagotto Romagnolo, Welsh Springer Spaniel, Weimaraner, English Cocker Spaniel, Labrador Retriever, Kooikerhondje, Barbet, Sussex Spaniel, Cocker Spaniel, Curly-Coated Retriever, American Water Spaniel, Irish Setter, Spinone, Clumber Spaniel, Pointer, Irish Water Spaniel, Nova Scotia Duck Tolling Retriever, Irish Red and White Setter, Chesapeake Bay Retriever, Gordon Setter, Golden Retriever, German Shorthaired Pointer, Brittany, Bracco Italiano, Bulldog, German Wirehaired Pointer
Research Program Area: Oncology - Lymphoma
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Abstract

The purpose of this study is to identify different types of normal B cells in the canine immune system and therefore improve the ability to study B cell diseases in dogs. One aim of this study is to sequence different populations of B cells based on their location in the lymph node and spleen. The second aim is to sequence B cells in three different disorders: 1) a disease in English Bulldogs that causes non-neoplastic B cell expansion; 2) an aggressive form of small cell B cell lymphoma; 3) diffuse large B cell lymphoma, the most common form of lymphoma in dogs.

The investigators will compare gene expression changes in these B cell diseases to normal B cell subsets. This work will help to determine which type of B cell is affected in these disease states and which mechanisms are affected. By determining the mechanisms that drive disease, we can identify potential therapeutic targets to improve the treatment of these diseases. The goal of this work is to advance our knowledge of the immune system in dogs and improve the understanding of three canine B cell diseases.

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