02461-A: Innate immune response to Leptospira in naturally exposed dogs

Grant Status: Closed

Grant Amount: $15,000
Sreekumari Rajeev, BVSc, PhD; Ross University School of Veterinary Medicine
December 1, 2017 - November 30, 2018

Sponsor(s): AKC Reunite

Breed(s): -All Dogs
Research Program Area: Immunology and Infectious Disease
Donate to Support this Research Program Area


Leptospirosis is a zoonotic disease of global occurrence and may result in life threatening illness in animals and humans. Leptospira may also reside in the kidney of many animal species including dogs without causing disease. Factors predisposing to clinical disease, carrier stage, or protection needs to be clarified. Dog are susceptible to fatal illness and at the same time may serve as asymptomatic reservoirs. Protection from vaccines is short-lived and suboptimal. Information available on immune response in naturally infected dogs is sparse. The investigators hope to unravel the host and pathogen factors in Leptospira infection that leads to fatal disease, chronic asymptomatic infection, or bacterial clearance. Innate immune cells are the first line of defense against Leptospira infection, initial experiments will determine the response of innate immune cells of dogs. The knowledge acquired from this study will be beneficial for the development of control and treatment strategies for this problematic and life-threatening disease. As leptospirosis is a zoonotic disease where animal, human and environmental interface is essential for transmission, the findings from this study will have a "One Health" impact.


Rajeev, S., Toka, F. N., & Shiokawa, K. (2020). Potential use of a canine whole blood culture system to evaluate the immune response to Leptospira. Comparative Immunology, Microbiology and Infectious Diseases, 101546. https://doi.org/10.1016/j.cimid.2020.101546

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software