02455-A: Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels

Abstract

English cocker spaniels (ECSs) are about 7 times more likely than other dog breeds to develop anal sac carcinoma (ASC). Hence, there appears to be a genetic basis for this disease development in ECSs. The investigators will sequence the genomes and transcriptomes of blood and ASC tumor samples collected from ECS dogs across the US. The samples will be studied alongside the pedigree information and medical records. Using dog-human comparative genomics and oncology strategy for cancer-causative mutation discovery, successful identification of mutations in ASC development in ECSs may lead to the development of genetic tests of this aggressive disease in ECSs and yield targets for therapeutic intervention.

Publication(s)

Mengyuan Zhang, Kun-Lin Ho, Shaying Zhao (2024) Initial Characterization of Canine T-cell Receptor Repertoires Using RNA-seq Data from Different Diseases and Tissues,  bioRxiv 2024.02.14.580390; doi: https://doi.org/10.1101/2024.02.14.580390

Wang, J., Wang, T., Sun, Y., Feng, Y., Kisseberth, W. C., Henry, C. J., … Zhao, S. (2018). Proliferative and Invasive Colorectal Tumors in Pet Dogs Provide Unique Insights into Human Colorectal Cancer. Cancers, 10(9), 330. https://doi.org/10.3390/cancers10090330

Zhang, M., Liu, D., Tang, J., Feng, Y., Wang, T., Dobbin, K. K., … Zhao, S. (2018). SEG - A Software Program for Finding Somatic Copy Number Alterations in Whole Genome Sequencing Data of Cancer. Computational and Structural Biotechnology Journal, 16, 335–341. https://doi.org/10.1016/j.csbj.2018.09.001