02098-A: Measurement of a Cardiac Muscle Development Protein to Enhance Diagnosis and Prognosis of Cardiomyopathy
Grant Status: Closed
Project Summary
This project sought to determine whether a blood borne marker of arrhythmias and ARVC in humans, BIN-1, is decreased in Boxer dogs with ARVC. This was not found to be the case in this small study, in which BIN-1 was found to be similar among groups of healthy dogs and those with cardiac disease. BIN-1 was found to increase with age, but was not related to any of the measures of heart disease or function studied. It is possible that the study was underpowered to demonstrate small differences among groups, but on the basis of our findings, even if differences exist between groups, there is likely to be extensive overlap between values, making it difficult to utlilize BIN-1 as a prognostic marker.
Publication(s)
None at this time.
Related Grants
- 00228T: A Comparative Evaluation of the Concealed and Overt Forms of Arrhythmogenic Right Ventricular Cardiomyopathy: Risk Factors Associated with the Development of Symptoms in Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy
- 440: A Molecular Evaluation of Two Forms of Canine Cardiomyopathy
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
