02093-A: Sequencing Histiocytic Sarcoma (HS) loci identified by Genetic Association studies in the Bernese Mountain Dog (BMD)
Grant Status: Closed
Histiocytic sarcoma (HS) occur at a high incidence in few breeds, specifically in Bernese Mountain Dogs (BMD), Rottweilers and Retrievers. Dr. Andre and her team have previously identified main genomic regions associated with HS in the BMD breed. The validations of these regions on over 1000 French BMDs allowed them to develop a first genetic "pre-test" to estimate the risk of developing and transmitting HS in BMDs. This pre-test, now available for breeders, is a first tool to progressively reduce the frequency of this cancer in BMDs. While major regions involved in HS are known, involved genes and mutations are still unknown. Breed structure is expected to be powerful to study the genetics of complex traits such as cancers and to reduce large regions of association. The analysis of affected Rottweilers allowed Dr. Andre and her team to reduce the main region of CFA11 to 200 Kb and to confirm the involvement of a second region on CFA11. Using this multiple breed-strategy, they analyzed affected Rottweilers and Retrievers, and selected 3 main loci involved in HS predisposition. Sequencing these loci is now mandatory to determine the genetic alterations leading to the susceptibility for HS in BMDs. These experiments will lead them to improve the present genetic testing (Pre-test), improve diagnosis and test and use more adequate treatments for HS in BMDs. Funding for the research is provided through the efforts and generosity of the Berner Lovers donor advised fund. The AKC Canine Health Foundation supports the funding of this effort and will oversee administration of funds and scientific progress reporting.
None at this time.
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