01683-A: Improving Resection of Tumors through Enhanced Imaging

Grant Status: Closed

Grant Amount: $12,960
David E Holt, BVSc; University of Pennsylvania
November 1, 2011 - April 30, 2014

Sponsor(s): Siberian Husky Club of America

Breed(s): -All Dogs
Research Program Area: Oncology
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In spite of our improved understanding of cancer molecular biology, the majority of curative cancer treatments include surgical resection of the tumor. Inadequate resection of all cancerous tissue during surgery significantly contributes to the morbidity and mortality of the disease. When "curative" surgery is attempted but incomplete surgical margins are obtained, dogs can develop both local cancer recurrence and distant metastatic disease. The goal of the current proposal is to evaluate an innovative, new, handheld intra-operative imaging system that detects probes (dyes) that accumulate within tumors. By using this instrument, surgeons can assess proposed surgical margins intra-operatively and examine the surgical field for residual cancerous tissue after the primary tumor has been removed. If the cancer-targeted probe is detected in the remaining tissue, additional tissue can be removed, decreasing the likelihood of tumor recurrence or metastases. Dr. Holt's study will evaluate this imaging system in canine cutaneous and subcutaneous sarcomas and compare the tumor and its margins as detected by the imaging system to histopathology of the same areas.


Holt, D., Parthasarathy, A. B., Okusanya, O., Keating, J., Venegas, O., Deshpande, C., … Singhal, S. (2015). Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds. Journal of Biomedical Optics, 20(7), 076002. https://doi.org/10.1117/1.JBO.20.7.076002

Madajewski, B., Judy, B. F., Mouchli, A., Kapoor, V., Holt, D., Wang, M. D., … Singhal, S. (2012). Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease. Clinical Cancer Research, 18(20), 5741–5751. https://doi.org/10.1158/1078-0432.CCR-12-1188

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