01178-A: Radiosensitization of Canine Osteosarcoma with Rapamycin

Grant Status: Closed

Grant Amount: $12,952.47
Michael S. Kent, DVM; University of California, Davis
July 1, 2008 - March 31, 2009

Sponsor(s): Akita Club of America, Inc., American Boxer Charitable Foundation, Flat-Coated Retriever Foundation, German Wirehaired Pointer Club of America, Golden Retriever Foundation, Great Dane Club of America, Great Dane Club of America Charitable Trust, Great Pyrenees Club of Puget Sound, Greyhound Club of America, Irish Setter Club of America Foundation, Irish Wolfhound Association of the West Coast, Irish Wolfhound Club of America, Inc., Jeffrey Pepper, Leonberger Health Foundation, Mastiff Club of America, Rhodesian Ridgeback Club of the United States, Rottweiler Health Foundation, Saluki Health Research, Inc., Starlight Fund

Breed(s): -All Dogs
Research Program Area: Oncology - Osteosarcoma
Donate to Support this Research Program Area

Project Summary

Osteosarcoma in the dog is a highly aggressive cancer that is often fatal. Management of this disease involves controlling the local tumor as well as its regional and distant metastasis. Despite aggressive therapy with radiation therapy, surgery and chemotherapy, median survival is about one year. The AKT/mTOR pathway is constitutively active in many forms of human cancer. We have found that this pathway is also activated in canine osteosarcoma. We have also shown that this pathway can be blocked using the drug rapamycin. Several studies in human cancer cell lines have shown that rapamycin can increase the radiosensitivity of in vitro. The goals of this study were to test the effect that the combinations of rapamycin and radiation have on cellular proliferation, clonogenicity and cell cycle kinetics in canine osteosarcoma. Results suggest that treatment intensification by a 2-week interradiation treatment interval coupled with interradiation chemotherapy is an effective treatment for dogs.


Lurie, D. M., Gordon, I. K., Théon, A. P., Rodriguez, C. O., Suter, S. E., & Kent, M. S. (2009). Sequential low-dose rate half-body irradiation and chemotherapy for the treatment of canine multicentric lymphoma. Journal of Veterinary Internal Medicine, 23(5), 1064–1070. https://doi.org/10.1111/j.1939-1676.2009.0353.x
Lurie, D. M., Kent, M. S., Fry, M. M., & Théon, A. P. (2008, December 1). A toxicity study of low?dose rate half?body irradiation and chemotherapy in dogs with lymphoma. https://doi.org/10.1111/j.1476-5829.2008.00164.x

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software