1004: Syringomyelia in the Brussels Griffon: Magnetic Resonance Imaging Findings, Clinicopathology, and Prevalence

Grant Status: Closed

Grant Amount: $140,482
Marc Kent, DVM; University of Georgia
April 1, 2008 - September 30, 2012

Sponsor(s): American Brussels Griffon Association, American Cavalier King Charles Spaniel Club Charitable Trust, Griffon Bruxellois Breeders Association, Griffon Bruxellois Club of Victoria

Breed(s): Brussels Griffon
Research Program Area: Neurology
Donate to Support this Research Program Area


Background: Syringomyelia (SM) has emerged as a common spinal cord abnormality in small breed dogs. 11 Syringomyelia, characterized by the development of fluid filled spinal cord cavitations or syrinxes, is associated with a syndrome of severe pain and weakness. Certain breeds are predisposed to SM, most notably the Cavalier King Charles Spaniel (CKCS). In the CKCS, SM is associated with a condition referred to as a Chiari-like malformation (CM), which is a developmental abnormality of the skull. As a result of the skull malformation, part of the cerebellum and the brainstem may be compressed leading to an alteration in the normal flow of cerebrospinal fluid (CSF) and mild inflammation in the central nervous system. It is hypothesized that these abnormalities contribute to the development of SM. Recently, SM has been diagnosed in Brussels Griffon (Griffon Bruxellois) dogs in North America, Europe and Australia. Objective: The researchers' hypothesis is that a subpopulation of the Brussels Griffon (BG) dog breed is affected by SM. Their goals are to identify the prevalence of SM in BG; to delineate clinical signs and spinal fluid abnormalities in BG with SM; and to utilize MRI to define structural abnormalities associated with SM in the BG breed.


Freeman, A. C., Platt, S. R., Kent, M., Huguet, E., Rusbridge, C., & Holmes, S. (2014). Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogs. Journal of Veterinary Internal Medicine, 28(5), 1551–1559. https://doi.org/10.1111/jvim.12421

Knowler, S. P., McFadyen, A. K., Freeman, C., Kent, M., Platt, S. R., Kibar, Z., & Rusbridge, C. (2014). Quantitative Analysis of Chiari-Like Malformation and Syringomyelia in the Griffon Bruxellois Dog. PLoS ONE, 9(2), e88120. https://doi.org/10.1371/journal.pone.0088120

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813


© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.