00947B: Heritable and Sporadic Genetic Lesions in Canine Osteosarcoma

Grant Status: Closed

Grant Amount: $184,443
Jaime F Modiano, VMD, PhD; University of Minnesota
July 1, 2008 - December 31, 2010

Sponsor(s): Golden Retriever Foundation

Breed(s): Golden Retriever, Rottweiler
Research Program Area: Oncology - Osteosarcoma
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Project Summary

Osteosarcoma is a common and deadly disease that occurs in most large and giant breed dogs, although some risk factors appear to be independent of size or body mass. There are currently no predictors for response to therapy or outcome. The use of robust array technology and bioinformatics has allowed us to re-enforce the concept that a dogs' genetic background (defined by breed) modulates the characteristics of the tumor, including both karyotype and gene expression profiles. These profiles are a first step in identifying potential risk factors that may underlie breed predisposition, and have generated results that may be useful to develop a predictive signature that can be used in the decision-making process regarding treatment decisions. The data also have been applied to comparative analyses of human osteosarcomas, confirming the supposition that canine osteosarcoma and human osteosarcoma share significant biological properties, and lessons from one disease can be extrapolated to the other.


Thayanithy, V., Sarver, A. L., Kartha, R. V., Li, L., Angstadt, A. Y., Breen, M., … Subramanian, S. (2012). Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. Bone, 50(1), 171–181. https://doi.org/10.1016/j.bone.2011.10.012

Thomas, R., Wang, H. J., Tsai, P.-C., Langford, C. F., Fosmire, S. P., Jubala, C. M., … Breen, M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research, 17(3), 365–377. https://doi.org/10.1007/s10577-009-9028-z

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