00336A: Mapping of the Gene for Malignant Histiocytosis in the Bernese Mountain Dog

Grant Status: Closed

Grant Amount: $54,700
Elaine A Ostrander, PhD; National Human Genome Research Institute
April 1, 2005 - March 31, 2007

Sponsor(s): Chinese Shar-Pei Charitable Trust

Breed(s): Bernese Mountain Dog, Rottweiler, Flat-Coated Retriever, Golden Retriever
Research Program Area: Oncology
Donate to Support this Research Program Area


We are interested in finding the genes that predispose the Bernese Mountain Dog (BMD) to malignant histiocytosis (MH) for three reasons. First, we are interested in improving the health of this increasingly popular breed, which is severely affected by this deadly disease. Finding the underlying disease gene will lead to the development of genetic tests that can ultimately generate improvements in breeding programs. Second, once we know the underlying cause of MH we can begin to work toward targeted therapies that improve both life, quality and duration for affected dogs. Finally, we are interested in the genetics of similar disorders affecting humans. We propose two complementary strategies: 1) Family based linkage analysis to track the disease gene in a large BMD family affected with MH; and 2) An association-based linkage study encompassing a minimum of 119 affected and at least 100 unaffected control dogs. Both approaches can be expected to highlight regions of the genome where a gene of interest may lie. In summary, these approaches will allow us to eliminate false positive results, increase statistical power for fine linkage mapping, and provide a large resource for mutation screening.


Shearin, A. L., Hedan, B., Cadieu, E., Erich, S. A., Schmidt, E. V., Faden, D. L., … Ostrander, E. A. (2012). The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer. Cancer Epidemiology Biomarkers & Prevention, 21(7), 1019–1027. https://doi.org/10.1158/1055-9965.EPI-12-0190-T

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software